Cullin 2 抗体 (Middle Region)
Quick Overview for Cullin 2 抗体 (Middle Region) (ABIN3043009)
抗原
See all Cullin 2 (CUL2) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 264-280, Middle Region
-
原理
- Anti-Cullin 2/CUL2 Antibody
-
序列
- HECQQRMVAD HLQFLHA
-
交叉反应 (详细)
- No cross-reactivity with other proteins
-
产品特性
- Anti-Cullin 2/CUL2 Antibody (ABIN3043009). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human Cullin 2, different from the related mouse and rat sequences by one amino acid.
-
亚型
- IgG
-
-
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
-
说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
-
储存液
- Thimerosal (Merthiolate), Sodium azide
-
注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
-
-
- Cullin 2 (CUL2)
-
别名
- CUL2
-
背景
-
Synonyms: Cullin-2,CUL-2,CUL2,
Background: Cullin 2 (CUL2) is a protein that in humans is encoded by the CUL2 gene. Using immunofluorescence, they showed that CUL2 is a cytosolic protein that can be translocated to the nucleus by VHL. By fluorescence in situ hybridization, Clifford et al. (1999)mapped the CUL2 gene to 10p11.2-p11.1, a region reported to show loss of heterozygosity (LOH) in several forms of human cancer, including non-clear cell renal cell carcinoma. Pause et al. (1997)suggested that CUL2 is a candidate tumor suppressor gene, as has been proposed for CUL1 (603134). Lonergan et al. (1998) demonstrated that formation of the VBC-CUL2 complexes is linked to the regulation of hypoxia-inducible mRNAs by VHL. Cul2 was one of several proteins required for degradation of a class of RNA-binding germline proteins in somatic cells of the early blastomere.
-
分子量
- 37 kDa
-
UniProt
- Q13617
-
途径
- M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interactome
抗原
-