ASIC3 抗体 (N-Term)
(1 reference)Quick Overview for ASIC3 抗体 (N-Term) (ABIN3042990)
抗原
See all ASIC3 (ACCN3) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 56-73, N-Term
-
原理
- Anti-Acid-sensing ion channel 3 ASIC3 Antibody Picoband®
-
序列
- FLYQVAERVR YYREFHHQ
-
交叉反应 （详细）
- No cross-reactivity with other proteins
-
产品特性
- Anti-Acid-sensing ion channel 3 ASIC3 Antibody (ABIN3042990). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human ASIC3, different from the related rat and mouse sequences by two amino acids.
-
亚型
- IgG
-
-
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (AA 62-320) antibody
ACCN3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (AA 53-102) antibodyACCN3 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (N-Term) antibodyACCN3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (N-Term) antibodyACCN3 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (AA 2-16), (Intracellular) antibodyACCN3 适用: 大鼠 WB, IHC, IF 宿主: 豚鼠 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (AA 1-549) antibodyACCN3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (AA 2-16), (Intracellular) antibodyACCN3 适用: 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 3 (ACCN3) (Internal Region) antibodyACCN3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Babinski, K., Le, K.-T., Seguela, P. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. J. Neurochem. 72: 51-57, 1999. 2. Birdsong, W. T., Fierro, L., Williams, F. G., Spelta, V., Naves, L. A., Knowles, M., Marsh-Haffner, J., Adelman, J. P., Almers, W., Elde, R. P., McCleskey, E. W. Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. Neuron 68: 739-749, 2010. 3. de Weille, J. R., Bassilana, F., Lazdunski, M., Waldmann, R. Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. FEBS Lett. 433: 257-260, 1998. -
说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
-
储存液
- Thimerosal (Merthiolate), Sodium azide
-
注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
-
-
-
: "Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers." in: The Journal of biological chemistry, Vol. 293, Issue 5, pp. 1756-1766, (2018) (PubMed).
-
: "Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers." in: The Journal of biological chemistry, Vol. 293, Issue 5, pp. 1756-1766, (2018) (PubMed).
-
- ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))
-
别名
- ASIC3
-
背景
-
Synonyms: Acid-sensing ion channel 3,ASIC3,hASIC3,Amiloride-sensitive cation channel 3,Neuronal amiloride-sensitive cation channel 3,Testis sodium channel 1,hTNaC1,ASIC3,ACCN3, SLNAC1, TNAC1,
Tissue Specificity: Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. .
Background: ASIC3 (Acid-Sensing Ion Channel3), also known as TESTIS SODIUM CHANNEL 1 (TNAC1) or DORSAL ROOT ACID-SENSING ION CHANNEL (DRASIC), is a protein that in humans is encoded by the ASIC3 gene. ASIC3 belongs to a family of acid-sensing channel proteins that are structurally related to epithelial sodium channel proteins and support acid-activated membrane currents. By radiation hybrid analysis, de Weille et al. (1998) mapped the ACCN3 gene to chromosome 7q35. De Weille et al. (1998) found that human ASIC3 supported an H (+)-gated cation current in COS cells with kinetics similar to those of rat Asic3. Babinski et al. (1999) expressed homomeric human ASIC3 channels in Xenopus oocytes and found that rapid reduction in extracellular pH resulted in a biphasic response characterized by a fast and rapidly desensitizing current followed by a slow and sustained current that returned to baseline only on return to physiologic pH .
Sequence Similarities: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily.
-
分子量
- 69 kDa
抗原
-
