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GLI2 抗体 (C-Term)

GLI2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042988
发货至: 中国
  • 抗原 See all GLI2 抗体
    GLI2 (GLI Family Zinc Finger 2 (GLI2))
    抗原表位
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1444-1463, C-Term
    适用
    • 27
    • 13
    • 6
    • 1
    宿主
    • 28
    • 2
    克隆类型
    • 28
    • 2
    多克隆
    标记
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GLI2 antibody is un-conjugated
    应用范围
    • 18
    • 12
    • 12
    • 6
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB)
    原理
    Anti-Zinc finger protein GLI2 Gli2 Antibody Picoband®
    序列
    MLYYYGQIHM YEQDGGLENL
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-Zinc finger protein GLI2 Gli2 Antibody (ABIN3042988). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the C-terminus of human Gli2.
    亚型
    IgG
    Top Product
    Discover our top product GLI2 Primary Antibody
  • 应用备注
    Western blot, 0.1-0.5 μg/mL, Human
    1. Bertolacini, C. D. P., Ribeiro-Bicudo, L. A., Petrin, A., Richieri-Costa, A., Murray, J. C. Clinical findings in patients with GLI2 mutations--phenotypic variability. Clin. Genet. 81: 70-75, 2012. 2. Matsumoto, N., Fujimoto, M., Kato, R., Niikawa, N. Assignment of the human GLI2 gene to 2q14 by fluorescence in situ hybridization. Genomics 36: 220-221, 1996. 3. Roessler, E., Ermilov, A. N., Grange, D. K., Wang, A., Grachtchouk, M., Dlugosz, A. A., Muenke, M. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum. Molec. Genet. 14: 2181-2188, 2005.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • Xiang, Jiang, Guo, Gong, Yang, Wu, Huang, Cheng, Xu: "Hedgehog pathway inhibitor-4 suppresses malignant properties of chondrosarcoma cells by disturbing tumor ciliogenesis." in: Oncology reports, Vol. 32, Issue 4, pp. 1622-30, (2014) (PubMed).

  • 抗原
    GLI2 (GLI Family Zinc Finger 2 (GLI2))
    别名
    GLI2 (GLI2 产品)
    背景

    Synonyms: Zinc finger protein GLI2 ,GLI family zinc finger protein 2 ,Tax helper protein ,GLI2 ,THP ,

    Tissue Specificity: Isoform 1 and isoform 4 are expressed in HTLV- 1-infected T-cell lines (at protein level). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines. Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines. .

    Background: GLI2 (Gli-Kruppel Family Member 2), also called ONCOGENE GLI2, is a protein that in humans is encoded by the GLI2 gene. Sequencing of GLI cDNA clones showed the presence of 5 tandem zinc fingers connected by histidine-cysteine links, which indicated that the gene belongs to the family of zinc finger genes related to Kruppel (Kr). The Drosophila gene Kr is a member of the gap class of segmentation genes, thoracic and anterior abdominal segments fail to form in Kr mutant embryos. By fluorescence in situ hybridization, Matsumoto et al. (1996) refined the assignment of the GLI2 gene to chromosome 2q14. Roessler et al. (2005) showed that GLI2-delta-N exhibited potent transcriptional activity in vivo: overexpression in mouse skin led to the formation of hedgehog-independent epithelial downgrowths resembling basal cell carcinomas, which in humans are associated with constitutive hedgehog signaling.

    Sequence Similarities: Belongs to the GLI C2H2-type zinc-finger protein family.

    分子量
    89 kDa
    UniProt
    P10070
    途径
    Hedgehog Signaling, Dopaminergic Neurogenesis
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