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Cadherin 5 抗体 (C-Term)

This anti-Cadherin 5 antibody is a 兔 多克隆 antibody detecting Cadherin 5 in WB 和 IHC. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN3042913
发货至: 中国

Quick Overview for Cadherin 5 抗体 (C-Term) (ABIN3042913)

抗原

See all Cadherin 5 (CDH5) 抗体
Cadherin 5 (CDH5)

适用

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  • 47
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  • 2
  • 2
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  • 1
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  • 1
人, 小鼠, 大鼠

宿主

  • 91
  • 44
  • 7
  • 1

克隆类型

  • 87
  • 56
多克隆

标记

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  • 8
  • 7
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
  • 1
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This Cadherin 5 antibody is un-conjugated

应用范围

  • 115
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  • 40
  • 15
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  • 13
  • 11
  • 7
  • 5
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  • 1
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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

    • 16
    • 13
    • 9
    • 7
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    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 766-784, C-Term

    原理

    Anti-VE-Cadherin CDH5-Antibody Picoband®

    序列

    RFKMLAELYG SDPREELLY

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-VE-Cadherin CDH5-Antibody (ABIN3042913). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human VE Cadherin, different from the related mouse and rat sequences by three amino acids.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
    1. Huber, P., Dalmon, J., Engiles, J., Breviario, F., Gory, S., Siracusa, L. D., Buchberg, A. M., Dejana, E. Genomic structure and chromosomal mapping of the mouse VE-cadherin gene (Cdh5). Genomics 32: 21-28, 1996. 2. Kremmidiotis, G., Baker, E., Crawford, J., Eyre, H. J., Nahmias, J., Callen, D. F. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. Genomics 49: 467-471, 1998.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • Dai, Chen, Lin, Wang, Guo, Zhang: "Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endothelial Dysfunction via miR-21." in: International journal of biological sciences, Vol. 13, Issue 7, pp. 868-877, (2018) (PubMed).

    Liu, Zhu, Xiong, Zheng, Hu, Qiu: "Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells." in: International journal of clinical and experimental pathology, Vol. 7, Issue 9, pp. 5750-61, (2014) (PubMed).

  • 抗原

    Cadherin 5 (CDH5)

    别名

    CDH5

    背景

    Synonyms: Cadherin-5,7B4 antigen,Vascular endothelial cadherin,VE-cadherin,CD144,CDH5,

    Tissue Specificity: Endothelial tissues and brain.

    Background: CDH5 (Cadherin 5), also known as VE-cadherin, is a type of cadherin. It is encoded by the human gene CDH5. Kremmidiotis et al. (1998) mapped the human CDH5 gene to 16q22.1 using somatic cell hybrid panels. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Therefore it was concluded that VE-cadherin serves the purpose of maintaining newly formed vessels.

    Sequence Similarities: Belongs to the annexin family.

    分子量

    130 kDa

    UniProt

    P33151

    途径

    Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2
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