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CXCR3 抗体 (AA 1-368)

Name: CXCR3 抗体 (AA 1-368)
SKU: ABIN3042780
Availability: OutOfStock

CXCR3 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

Anti-CXCR3 Picoband antibody, All lanes: Anti-CXCR3 at 0. (CXCR3 抗体 (AA 1-368))

Anti-CXCR3 Picoband antibody, IHC(P): Rat Kidney Tissue (CXCR3 抗体 (AA 1-368))

IHC

Anti-CXCR3 Picoband antibody, IHC(P): Human Lung Cancer Tissue (CXCR3 抗体 (AA 1-368))

IHC

Anti-CXCR3 Picoband antibody, IHC(P): Human Tonsil Tissue (CXCR3 抗体 (AA 1-368))

IHC

5 images

(2 references)

产品编号 ABIN3042780

发货至: 中国

Datasheet as PDF

抗原 See all CXCR3 抗体

CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
抗原表位
15

8

6

6

5

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 1-368
适用
90

43

12

1
人, 大鼠
宿主
75

22

10

1

1
兔
Compatible Secondaries
克隆类型
65

44
多克隆
标记
40

12

10

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This CXCR3 antibody is un-conjugated
应用范围
63

55

35

25

12

12

12

11

9

8

6

3

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-CXCR3 Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-CXCR3 Antibody Picoband® (ABIN3042780). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human CXCR3 recombinant protein (Position: M1-L368). Human CXCR3 shares 86% amino acid (aa) sequence identity with both mouse and rat CXCR3.

亚型

IgG

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anti-Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 301-367) antibody
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anti-Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (C-Term) antibody
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CXCR3 适用: 人, 小鼠 FACS, WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (Internal Region) antibody
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anti-Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (C-Term) antibody
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anti-Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 140-167) antibody
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anti-Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 147-175), (Middle Region) antibody
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anti-Chemokine (C-X-C Motif) Receptor 3 (CXCR3) antibody (FITC)
GMP Grade CXCR3 适用: 人 FACS 宿主: 小鼠 Monoclonal 1C6 FITC

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Western blot, 0.1-0.5 μg/mL, Human
1. Trentin, L., Agostini, C., Facco, M., Piazza, F., Perin, A., Siviero, M., Gurrieri, C., Galvan, S., Adami, F., Zambello, R., Semenzato, G. The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis. J. Clin. Invest. 104: 115-121, 1999. 2. Frigerio, S., Junt, T., Lu, B., Gerard, C., Zumsteg, U., Hollander, G. A., Piali, L. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nature Med. 8: 1414-1420, 2002. 3. Feferman, T., Maiti, P. K., Berrih-Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., Souroujon, M. C. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. J. Immun. 174: 5324-5331, 2005. 4. Struyf, S., Salogni, L., Burdick, M. D., Vandercappellen, J., Gouwy, M., Noppen, S., Proost, P., Opdenakker, G., Parmentier, M., Gerard, C., Sozzani, S., Strieter, R. M., Van Damme, J. Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. Blood 117: 480-488, 2011.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Ding, Xia, Ding, Lu, Sun, Liu: "An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+ liver cancer cells induced by CXCL9." in: Oncotarget, Vol. 7, Issue 12, pp. 14405-14, (2018) (PubMed).

Li, Zhu, Luo, Fang, Zhou, Hu, Maskey, Yang: "Impact of chemokine receptor CXCR3 on tumor-infiltrating lymphocyte recruitment associated with favorable prognosis in advanced gastric cancer." in: International journal of clinical and experimental pathology, Vol. 8, Issue 11, pp. 14725-32, (2016) (PubMed).
抗原

CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

别名

CXCR3 (CXCR3 产品)

背景

Synonyms: C-X-C chemokine receptor type 3,CXC-R3,CXCR-3,CKR-L2,G protein-coupled receptor 9,Interferon-inducible protein 10 receptor,IP-10 receptor,CD183,CXCR3,GPR9,
Tissue Specificity: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level). .
Background: Chemokine receptor CXCR3 is a Galphai protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. It is mapped to Xq13.1. CXCR3 is expressed on malignant B cells from chronic lymphoproliferative disorders, particularly in patients with CLL, and represents a fully functional receptor involved in chemotaxis of malignant B lymphocytes. It is found that in the absence of known etiologic agents, CXCR3 represents a novel target for therapeutic interference early in type 1 diabetes. CXCR3 signaling is associated with MG pathogenesis and proposed that and CXCR3 may serve as novel drug targets to treat MG. CXCR3A and CXCR3B are involved in the chemotactic and vascular effects of CXCL4L1.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

分子量

41 kDa

基因ID

2833

UniProt

P49682