Claudin 2 抗体 (AA 38-230)
(1 reference)Quick Overview for Claudin 2 抗体 (AA 38-230) (ABIN3042751)
抗原
See all Claudin 2 (CLDN2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 38-230
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原理
- Anti-Claudin 2/CLDN2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Claudin 2/CLDN2 Antibody (ABIN3042751). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Claudin 2 recombinant protein (Position: A38-V230). Human Claudin 2 shares 92% amino acid (aa) sequence identity with mouse Claudin 2.
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亚型
- IgG
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anti-Claudin 2 (CLDN2) (C-Term) antibody
CLDN2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Claudin 2 (CLDN2) (AA 30-230) antibodyCLDN2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Claudin 2 (CLDN2) (AA 29-80) antibodyCLDN2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F1 unconjugated
anti-Claudin 2 (CLDN2) (AA 200-227), (C-Term) antibodyCLDN2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB16648 unconjugated
anti-Claudin 2 (CLDN2) (AA 29-81) antibodyCLDN2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Claudin 2 (CLDN2) antibodyCLDN2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Claudin 2 (CLDN2) (C-Term) antibodyCLDN2 适用: 人, 小鼠, 大鼠, 犬 WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal unconjugated
anti-Claudin 2 (CLDN2) (AA 30-230) antibodyCLDN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Claudin 2 (CLDN2) (C-Term) antibodyCLDN2 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Claudin 2 (CLDN2) (AA 135-164) antibodyCLDN2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Rat, Human
1. Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A 96 (2): 511-6. 2. Sakaguchi, T., Gu, X., Golden, H. M., Suh, E., Rhoads, D. B., Reinecker, H.-C. Cloning of the human claudin-2 5-prime-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1-alpha. J. Biol. Chem. 277: 21361-21370, 2002. 3. Muto, S., Hata, M., Taniguchi, J., Tsuruoka, S., Moriwaki, K., Saitou, M., Furuse, K., Sasaki, H., Fujimura, A., Imai, M., Kusano, E., Tsukita, S., Furuse, M. (2010). "Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules". Proceedings of the National Academy of Sciences 107 (17): 8011-8016. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Alteration in P-glycoprotein at the blood-brain barrier in the early period of MCAO in rats." in: The Journal of pharmacy and pharmacology, Vol. 65, Issue 5, pp. 665-72, (2013) (PubMed).
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: "Alteration in P-glycoprotein at the blood-brain barrier in the early period of MCAO in rats." in: The Journal of pharmacy and pharmacology, Vol. 65, Issue 5, pp. 665-72, (2013) (PubMed).
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- Claudin 2 (CLDN2)
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别名
- CLDN2
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背景
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Synonyms: Claudin-2,SP82,CLDN2,PSEC0059, SP82, UNQ705/PRO1356,
Background: Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. By genomic sequence analysis, this gene is mapped to chromosome Xq22.3-q23. This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. By expression in a human intestinal epithelial cell line, it was determined that the intestine-specific homeodomain proteins CDX1 and CDX2 activated a reporter plasmid driven by the CLDN2 promoter.
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分子量
- 25 kDa
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基因ID
- 9075
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UniProt
- P57739
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途径
- Hepatitis C
抗原
-
