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HTR2A 抗体 (C-Term)

HTR2A 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042729
发货至: 中国
  • 抗原 See all HTR2A 抗体
    HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))
    抗原表位
    • 15
    • 14
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 400-431, C-Term
    适用
    • 63
    • 51
    • 49
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    人, 大鼠
    宿主
    • 68
    • 1
    • 1
    • 1
    克隆类型
    • 70
    • 1
    多克隆
    标记
    • 22
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HTR2A antibody is un-conjugated
    应用范围
    • 52
    • 25
    • 24
    • 20
    • 13
    • 11
    • 9
    • 6
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    Anti-5HT2A Receptor/HTR2A Antibody Picoband®
    序列
    KENKKPLQLI LVNTIPALAY KSSQLQMGQK KN
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-5HT2A Receptor/HTR2A Antibody Picoband® (ABIN3042729). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT2A Receptor , different from the related mouse sequence by three amino acids, and from the related rat sequence by two amino acids.
    亚型
    IgG
    Top Product
    Discover our top product HTR2A Primary Antibody
  • 应用备注
    Western blot, 0.1-0.5 μg/mL, Human, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat1. Cook EH, Fletcher KE, Wainwright M, Marks N, Yan SY, Leventhal BL (August 1994). "Primary structure of the human platelet serotonin 5-HT2 receptor: identity with frontal cortex serotonin 5-HT2A receptor". J. Neurochem. 63 (2): 465-9. 2. Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ (2004). "The human polyomavirus, JCV, uses serotonin receptors to infect cells". Science 306 (5700): 1380-3.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原
    HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))
    别名
    HTR2A (HTR2A 产品)
    背景

    Synonyms: 5-hydroxytryptamine receptor 2A,5-HT-2,5-HT-2A,Serotonin receptor 2A,HTR2A,HTR2,

    Tissue Specificity: Detected in brain cortex (at protein level). Detected in blood platelets. .

    Background: The mammalian HTR2A (5-HT2A receptor) is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbit frontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones. 5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus. Sparkes et al. (1991) concluded that the gene is located on 13q14-q21 in man and on chromosome 14 in the mouse.

    Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

    分子量
    53 kDa
    基因ID
    3356
    UniProt
    P28223
    途径
    JAK/STAT Signaling, Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process
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