Desmoglein 2 抗体 (C-Term)
Quick Overview for Desmoglein 2 抗体 (C-Term) (ABIN3042669)
抗原
See all Desmoglein 2 (DSG2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1104-1118, C-Term
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原理
- Anti-Desmoglein 2/DSG2 Antibody Picoband®
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序列
- STRVTKHSTV QHSYS
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Desmoglein 2/DSG2 Antibody (ABIN3042669). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Desmoglein 2, different from the related mouse and rat sequences by one amino acid.
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亚型
- IgG
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anti-Desmoglein 2 (DSG2) (AA 72-121) antibody
DSG2 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (N-Term) antibodyDSG2 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (N-Term) antibodyDSG2 适用: 人, 大鼠, 小鼠, Cow, 犬, Pig, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 275-533) antibodyDSG2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 183-331) antibodyDSG2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 37-164) antibodyDSG2 适用: 人 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal 10D2 unconjugated
anti-Desmoglein 2 (DSG2) (N-Term) antibodyDSG2 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) (AA 51-150) antibodyDSG2 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 2 (DSG2) antibodyDSG2 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 6D8 unconjugated
anti-Desmoglein 2 (DSG2) (AA 145-216), (N-Term) antibodyDSG2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB16855 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Arnemann J, Spurr NK, Magee AI, Buxton RS (Jul 1992). "The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18". Genomics 13 (2): 484-6. 2. "Entrez Gene: DSG2 desmoglein 2". mutations in DSG2 contribute to the development of ARVD/C. 3. Syrris, P., Ward, D., Asimaki, A., Evans, A., Sen-Chowdhry, S., Hughes, S. E., McKenna, W. J. Desmoglein-2 mutations in arrhythmogenic right ventricular cardiomyopathy: a genotype-phenotype characterization of familial disease. Europ. Heart J. 28: 581-588, 2007. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- Desmoglein 2 (DSG2)
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别名
- DSG2
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背景
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Synonyms: Desmoglein-2,Cadherin family member 5,HDGC,DSG2,CDHF5,
Tissue Specificity: All of the tissues tested and carcinomas.
Background: Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.
Sequence Similarities: Contains 4 cadherin domains.
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分子量
- 160 kDa
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UniProt
- Q14126
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途径
- Cell-Cell Junction Organization
抗原
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