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ICAM1 抗体 (AA 198-537)

This anti-ICAM1 antibody is a 兔 多克隆 antibody detecting ICAM1 in WB 和 IHC. Suitable for 小鼠 和 大鼠. This Primary Antibody has been cited in 37+ publications.
Pubmed (37 references)
产品编号 ABIN3042515
发货至: 中国

Quick Overview for ICAM1 抗体 (AA 198-537) (ABIN3042515)

抗原

See all ICAM1 抗体
ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

适用

  • 200
  • 45
  • 23
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  • 1
  • 1
小鼠, 大鼠

宿主

  • 124
  • 110
  • 22
  • 3
  • 3
  • 2
  • 1
  • 1
兔

克隆类型

  • 154
  • 107
  • 2
多克隆

标记

  • 148
  • 25
  • 21
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This ICAM1 antibody is un-conjugated

应用范围

  • 164
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  • 93
  • 69
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  • 50
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Western Blotting (WB), Immunohistochemistry (IHC)
Discover our top product ICAM1 Primary Antibody

  • 抗原表位

    • 23
    • 10
    • 9
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
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    AA 198-537

    原理

    Anti-ICAM1 Antibody Picoband®

    交叉反应 （详细）

    No cross-reactivity with other proteins

    产品特性

    Anti-ICAM1 Antibody Picoband® (ABIN3042515). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived mouse ICAM1 recombinant protein (Position: G198-P537). Mouse ICAM1 shares 74% amino acid (aa) sequence identity with rat ICAM1.

    亚型

    IgG
  • anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 201-300) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 201-300) antibody

    ICAM1 适用: 人, 小鼠, 大鼠, 兔 WB, FACS, ELISA, ICC, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

    anti-Intercellular Adhesion Molecule 1 (ICAM1) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) antibody

    ICAM1 适用: 人, 大鼠, Cow WB, FACS, ELISA, ICC, IHC (p) 宿主: 小鼠 Monoclonal MEM-111 unconjugated

    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 102-306) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 102-306) antibody

    ICAM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 41-464) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 41-464) antibody

    ICAM1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 18# unconjugated

    anti-Intercellular Adhesion Molecule 1 (ICAM1) (pTyr512) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) (pTyr512) antibody

    ICAM1 适用: 人, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 41-464) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 41-464) antibody

    ICAM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 27-209) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 27-209) antibody

    ICAM1 适用: Pig WB, IHC 宿主: 兔 Polyclonal unconjugated

    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 1-532) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 1-532) antibody

    ICAM1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3H8-2G6 unconjugated

    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 313-327) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 313-327) antibody

    Verified ICAM1 适用: 人 WB, FACS, ELISA, IF 宿主: 山羊 Polyclonal unconjugated

    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 250-480) antibody
    anti-Intercellular Adhesion Molecule 1 (ICAM1) (AA 250-480) antibody

    ICAM1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

  • 应用备注

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Mouse, Rat
    1. Ballantyne, C. M., Kozak, C. A., O'Brien, W. E., Beaudet, A. L. Assignment of the gene for intercellular adhesion molecule-1 (Icam-1) to proximal mouse chromosome 9. Genomics 9: 547-550, 1991. 2. Bella, J., Kolatkar, P. R., Marlor, C. W., Greve, J. M., Rossmann, M. G. The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand. Proc. Nat. Acad. Sci. 95: 4140-4145, 1998. 3. Simmons, D., Makgoba, M. W., Seed, B. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 331: 624-627, 1988.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用

  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Ma, Pan, Ren, Guo, Guo, Wei, Zheng, Chen: "15-oxoeicosatetraenoic acid mediates monocyte adhesion to endothelial cell." in: Lipids in health and disease, Vol. 16, Issue 1, pp. 137, (2018) (PubMed).

    Zhang, Wang, Tian, Zhang, Yang, Tao, Liang, Li, Yu, Tang, Tang, Zhou, Kong, Du, Huang, Jin: "The Increased Endogenous Sulfur Dioxide Acts as a Compensatory Mechanism for the Downregulated Endogenous Hydrogen Sulfide Pathway in the Endothelial Cell Inflammation." in: Frontiers in immunology, Vol. 9, pp. 882, (2018) (PubMed).

    Ma, Pan, Chen, Guo, Zhao, Zheng, Chen: "Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion." in: Bioscience reports, Vol. 37, Issue 2, (2017) (PubMed).

    Wang, Sun, Shen, Wu, Liu, Yang, Ji, Ji, Li: "Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB." in: Oxidative medicine and cellular longevity, Vol. 2015, pp. 970156, (2016) (PubMed).

    Pan, Wang, Pu, Yao, Wang: "Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 21, pp. 2134-40, (2016) (PubMed).

    Wang, Wang, Li, Wu, Liu, Yang, Ji, Ji, Li: "The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress." in: PLoS ONE, Vol. 10, Issue 11, pp. e0142571, (2016) (PubMed).

    Tian, Wang, Cao, Zhong, Tu, Xiao, He, Zhai: "Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits." in: Chinese journal of integrative medicine, Vol. 21, Issue 3, pp. 229-33, (2015) (PubMed).

    Cheng, Zhang, Song, Feng: "Intercellular adhesion molecule-1 expression in the hippocampal CA1 region of hyperlipidemic rats with chronic cerebral ischemia." in: Neural regeneration research, Vol. 7, Issue 17, pp. 1312-7, (2015) (PubMed).

    Ning, Liu, Lv, Yang, Zhang, Yu, Wang, Zhu: "Lipid metabolism and inflammation modulated by Vitamin D in liver of diabetic rats." in: Lipids in health and disease, Vol. 14, pp. 31, (2015) (PubMed).

    Chen, Zhang, Chen, Liu, Wang, Zhou, Qiu, Zhang, Teng, Mao, Liu, Wei, Li: "Retinoic Acid promotes interleukin-4 plasmid-dimethylsulfoxide topical transdermal delivery for treatment of psoriasis." in: Annals of dermatology, Vol. 27, Issue 2, pp. 121-7, (2015) (PubMed).

    Fan, Yao, Li, Hu, Shao, Tian: "Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb." in: International journal of clinical and experimental pathology, Vol. 8, Issue 4, pp. 3451-9, (2015) (PubMed).

    Huang, Huang, Xiao, Yang, Lin, Diao: "Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-?B signaling pathway." in: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 68, Issue 4, pp. 455-61, (2014) (PubMed).

    Wang, Zhao, Fang, Li, Shen, Cao, Zhu: "Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response." in: Critical care, Vol. 17, Issue 2, pp. R44, (2014) (PubMed).

    Fan, Jing, Yao, Li, Hu, Shao, Shen, Pan, Luo, Tian: "The protective effects of curcumin on experimental acute liver lesion induced by intestinal ischemia-reperfusion through inhibiting the pathway of NF-?B in a rat model." in: Oxidative medicine and cellular longevity, Vol. 2014, pp. 191624, (2014) (PubMed).

    Wang, Shen, Li, Wang, Zhang: "2,3,4',5-tetrahydroxystilbene-2-O-?-D-glucoside suppresses expression of adhesion molecules in aortic wall of dietary atherosclerotic rats and promonocytic U937 cells." in: Cell biochemistry and biophysics, Vol. 67, Issue 3, pp. 997-1004, (2013) (PubMed).

    Yu, Chen, Wang, Kuang, Liu, Zhang, Du: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." in: PLoS ONE, Vol. 8, Issue 2, pp. e55839, (2013) (PubMed).

    Xu, Feng, Wang, Zhu, Lin, Lou, Xiang, He, Zheng, Tang, Zuo: "Phytoestrogen calycosin-7-O-?-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage." in: Journal of cellular biochemistry, Vol. 112, Issue 10, pp. 2953-65, (2011) (PubMed).

    Cui, Tian, Bai: "Protective effects of propofol on endotoxemia-induced acute kidney injury in rats." in: Clinical and experimental pharmacology & physiology, Vol. 38, Issue 11, pp. 747-54, (2011) (PubMed).

    Zhu, Lv, Chen, Wang, Zhong: "Protective effect and mechanism of sodium tanshinone II A sulfonate on microcirculatory disturbance of small intestine in rats with sepsis." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 31, Issue 4, pp. 441-5, (2011) (PubMed).

    Ji, Gao, Cai, Lu, Hu, Wang, Cheng, Gu, Wan, Zhang, Cao: "Immunological regulation of Chinese herb Guizhi Fuling Capsule on rat endometriosis model." in: Journal of ethnopharmacology, Vol. 134, Issue 3, pp. 624-9, (2011) (PubMed).

    show more references

  • 抗原

    ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

    别名

    ICAM1

    背景

    Synonyms: Intercellular adhesion molecule 1,ICAM-1,MALA-2,MyD10,CD54,Icam1,Icam-1,

    Tissue Specificity: Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells.

    Background: Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for lymphocyte function-associated (LFA) antigens, a beta 2 leukocyte integrin. The normal function of human ICAM-1 is to provide adhesion between endothelial cells and leukocytes after injury or stress. ICAM-1 binds to leukocyte function-associated antigen (LFA-1) or macrophage-1 antigen (Mac-1). It is found on leukocytes, fibroblasts, epithelial cells and endothelial cells and its expression is regulated by inflammatory cytokines. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses.

    Sequence Similarities: Belongs to the immunoglobulin superfamily. ICAM family.

    分子量

    90-100 kDa

    基因ID

    15894

    UniProt

    P13597

    途径

    Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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