Lamin B1 抗体 (AA 266-583)
(15 references)Quick Overview for Lamin B1 抗体 (AA 266-583) (ABIN3042505)
抗原
See all Lamin B1 (LMNB1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 266-583
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原理
- Anti-Lamin B1/LMNB1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Lamin B1/LMNB1 Antibody Picoband® (ABIN3042505). Tested in Flow Cytometry, IP, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Lamin B1 recombinant protein (Position: Q266-C583). Human Lamin B1 shares 95.9% and 95% amino acid (aa) sequence identity with mouse and rat Lamin B1, respectively.
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亚型
- IgG
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anti-Lamin B1 (LMNB1) (AA 397-586) antibody
LMNB1 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Lamin B1 (LMNB1) (AA 52-233) antibodyLMNB1 适用: 人 WB 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Lamin B1 (LMNB1) (AA 107-186) antibodyLMNB1 适用: 人 WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Lamin B1 (LMNB1) (AA 107-186) antibodyLMNB1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4E4 unconjugated
anti-Lamin B1 (LMNB1) (AA 570-586), (C-Term) antibodyLMNB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lamin B1 (LMNB1) (AA 266-583) antibodyLMNB1 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lamin B1 (LMNB1) (AA 570-586) antibodyLMNB1 适用: 人, 大鼠 WB, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lamin B1 (LMNB1) antibodyKO Validated LMNB1 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lamin B1 (LMNB1) antibodyLMNB1 适用: 人, 小鼠, 大鼠 WB, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 4K2 unconjugated
anti-Lamin B1 (LMNB1) (AA 361-460) antibodyLMNB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL
Immunocytochemistry/Immunofluorescence, 5 μg/mL
Immunoprecipitation, 0.5-2 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
1. Pollard, K. M., Chan, E. K., Grant, B. J., Sullivan, K. E., Tan, E. M., Glass, C. A. : In vitro posttranslational modification of lamin B clones from a human T-cell line. Molec. Cell. Biol. 10: 2164-2175, 1990. 2. Tsai, M.-Y., Wang, S., Heidinger, J. M., Shumaker, D. K., Adam, S. A., Goldman, R. D., Zheng, Y. : A mitotic lamin B matrix induced by RanGTP required for spindle assembly. Science 311: 1887-1893, 2006. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation." in: Scientific reports, Vol. 6, pp. 30322, (2018) (PubMed).
: "Cellular and Molecular Features of Developmentally Programmed Genome Rearrangement in a Vertebrate (Sea Lamprey: Petromyzon marinus)." in: PLoS genetics, Vol. 12, Issue 6, pp. e1006103, (2017) (PubMed).
: "Overexpression of DJ-1 reduces oxidative stress and attenuates hypoxia/reoxygenation injury in NRK-52E cells exposed to high glucose." in: International journal of molecular medicine, Vol. 38, Issue 3, pp. 729-36, (2017) (PubMed).
: "Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway." in: Environmental toxicology, Vol. 32, Issue 8, pp. 2004-2020, (2017) (PubMed).
: "Glutamine ameliorates lipopolysaccharide-induced cardiac dysfunction by regulating the toll-like receptor 4/mitogen-activated protein kinase/nuclear factor-kB signaling pathway." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5825-5832, (2017) (PubMed).
: "Clinicopathologic and prognostic significance of p21 (Cip1/Waf1) expression in bladder cancer." in: International journal of clinical and experimental pathology, Vol. 8, Issue 5, pp. 4999-5007, (2016) (PubMed).
: "Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1." in: British journal of pharmacology, Vol. 173, Issue 3, pp. 545-61, (2016) (PubMed).
: "Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart." in: Scientific reports, Vol. 6, pp. 22068, (2016) (PubMed).
: "The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration." in: Scientific reports, Vol. 6, pp. 30563, (2016) (PubMed).
: "Activation of volume-sensitive outwardly rectifying chloride channel by ROS contributes to ER stress and cardiac contractile dysfunction: involvement of CHOP through Wnt." in: Cell death & disease, Vol. 5, pp. e1528, (2015) (PubMed).
: "Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility." in: Carcinogenesis, Vol. 35, Issue 8, pp. 1901-10, (2014) (PubMed).
: "Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling." in: BMC cancer, Vol. 14, pp. 686, (2014) (PubMed).
: "Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells." in: Journal of virology, Vol. 89, Issue 1, pp. 300-11, (2014) (PubMed).
: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." in: PLoS ONE, Vol. 8, Issue 2, pp. e55839, (2013) (PubMed).
: "Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells." in: British journal of pharmacology, Vol. 165, Issue 1, pp. 120-34, (2012) (PubMed).
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: "Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation." in: Scientific reports, Vol. 6, pp. 30322, (2018) (PubMed).
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- Lamin B1 (LMNB1)
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别名
- LMNB1
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背景
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Synonyms: Lamin-B1,LMNB1,LMN2, LMNB,
Tissue Specificity: Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. .
Background: Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.
Sequence Similarities: Belongs to the intermediate filament family.
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分子量
- 67 kDa
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基因ID
- 4001
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UniProt
- P20700
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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