FURIN 抗体 (AA 591-794)
Quick Overview for FURIN 抗体 (AA 591-794) (ABIN3042409)
抗原
See all FURIN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 591-794
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原理
- Anti-Furin Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Furin Antibody Picoband® (ABIN3042409). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Furin recombinant protein (Position: T591-L794). Human Furin shares 88% amino acid (aa) sequence identity with both mouse and rat Furin.
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亚型
- IgG
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anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 120-370) antibody
FURIN 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 587-748) antibodyFURIN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 418-573) antibodyFURIN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (Internal Region) antibodyVerified FURIN 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 385-500) antibodyFURIN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 578-734) antibodyFURIN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 520-701) antibodyFURIN 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) antibodyFURIN 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 1C3 unconjugated Recombinant Antibody
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) antibodyFURIN 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 105-221) antibodyFURIN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ (Jan 1991). "Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site". Proc Natl Acad Sci U S A 87(23): 9378-82. 2. Hallenberger S, Bosch V, Angliker H, Shaw E, Klenk HD, Garten W (November 1992). "Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160". Nature 360 (6402): 358-61. 3. Thomas G (October 2002). "Furin at the cutting edge: from protein traffic to embryogenesis and disease". Nat. Rev. Mol. Cell Biol. 3 (10): 753-66.doi:10.1038/nrm934. 4. Roebroek, A. J. M., Schalken, J. A., Leunissen, J. A. M., Onnekink, C., Bloemers, H. P. J., Van de Ven, W. J. M. Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein. EMBO J. 5: 2197-2202, 1986. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
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别名
- FURIN
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背景
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Synonyms: Furin,3.4.21.75,Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE,FURIN,FUR, PACE, PCSK3,
Tissue Specificity: Seems to be expressed ubiquitously.
Background: Furin (Fur), also known as PACE, is a protein that in humans is encoded by the FURIN gene. The protein encoded by this gene is an enzyme which belongs to the subtilisin-like proprotein convertase family. The Furin gene is located approximately 1 kb upstream of the FES gene on chromosome 15q25-q26. This gene is thought to play a role in tumor progression. Furin is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. Expression of furin in T-cells is required for maintenance of peripheral immune tolerance.
Sequence Similarities: Belongs to the peptidase S8 family. Furin subfamily.
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分子量
- 87 kDa
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基因ID
- 5045
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UniProt
- P09958
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途径
- Notch Signaling, Neurotrophin Signaling Pathway
抗原
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