FRZB 抗体 (AA 176-325)
Quick Overview for FRZB 抗体 (AA 176-325) (ABIN3042406)
抗原
See all FRZB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 176-325
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原理
- Anti-FRZB Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-FRZB Antibody Picoband® (ABIN3042406). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human FRZB recombinant protein (Position: E176-N325). Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.
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亚型
- IgG
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anti-Frizzled-Related Protein (FRZB) (AA 1-325) antibody
FRZB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (C-Term) antibodyFRZB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (Middle Region) antibodyFRZB 适用: 人, 小鼠, 大鼠, 马, Cow, 犬, 豚鼠, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 166-325) antibodyFRZB 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 59-108) antibodyFRZB 适用: 人, 大鼠, 马, Cow, 豚鼠, 兔, Bat, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 102-190) antibodyFRZB 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E5 unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 102-190) antibodyFRZB 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 102-190) antibodyFRZB 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F4 unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 216-265) antibodyFRZB 适用: 人, 小鼠, 大鼠, 马, 犬, Bat, 猴, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled-Related Protein (FRZB) (AA 166-325) antibodyFRZB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, -
ELISA, 0.1-0.5 μg/mL, -
1. Baker-Lepain JC, et al. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. Arthritis Rheum, 2012 May. 2. Qin S, et al. FRZB knockdown upregulates β-catenin activity and enhances cell aggressiveness in gastric cancer. Oncol Rep, 2014 May. 3. Wasmann RA, et al. Novel membrane frizzled-related protein gene mutation as cause of posterior microphthalmia resulting in high hyperopia with macular folds. Acta Ophthalmol, 2014 May. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- FRZB (Frizzled-Related Protein (FRZB))
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别名
- FRZB
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背景
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Synonyms: Secreted frizzled-related protein 3,sFRP-3,Frezzled,Fritz,Frizzled-related protein 1,FrzB-1,FRZB,FIZ, FRE, FRP, FRZB1, SFRP3,
Tissue Specificity: Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver.
Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.
Sequence Similarities: Belongs to the secreted frizzled-related protein (sFRP) family.
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分子量
- 36 kDa
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基因ID
- 2487
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UniProt
- Q92765
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途径
- WNT signaling, Positive Regulation of fat Cell Differentiation
抗原
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