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FOXP3 抗体 (AA 101-431)

Name: FOXP3 抗体 (AA 101-431)
SKU: ABIN3042405
Availability: OutOfStock

FOXP3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated

Anti-FOXP3 Picoband antibody, IHC(P):Rat Spleen Tissue (FOXP3 抗体 (AA 101-431))

IHC

Anti-FOXP3 Picoband antibody, IHC(P): Mouse Spleen Tissue (FOXP3 抗体 (AA 101-431))

IHC

Anti-FOXP3 Picoband antibody, IHC(P): Human Tonsil Tissue (FOXP3 抗体 (AA 101-431))

IHC

3 images

(10 references)

产品编号 ABIN3042405

发货至: 中国

Datasheet as PDF

抗原 See all FOXP3 抗体

FOXP3 (Forkhead Box P3 (FOXP3))
抗原表位
16

15

11

8

6

6

6

5

5

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 101-431
适用
147

123

55

26

6

3

3

2

2

1

1

1

1
人, 小鼠, 大鼠
宿主
109

61

15
兔
Compatible Secondaries
克隆类型
106

79
多克隆
标记
89

15

10

10

7

4

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1
This FOXP3 antibody is un-conjugated
应用范围
118

75

61

38

37

34

27

18

18

16

9

8

6

6

4

3

2

2

1

1

1

1

1
Immunohistochemistry (IHC)

原理

Anti-Forkhead box protein P3 FOXP3 Antibody

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Forkhead box protein P3 FOXP3 Antibody (ABIN3042405). Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human FOXP3 recombinant protein (Position: H101-P431). Human FOXP3 shares 88% amino acid (aa) sequence identity with mouse FOXP3.

亚型

IgG

Top Product

Discover our top product FOXP3 Primary Antibody
anti-Forkhead Box P3 (FOXP3) (AA 190-412) antibody
FOXP3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Forkhead Box P3 (FOXP3) (AA 297-431) antibody
FOXP3 适用: 人 FACS, ELISA, IHC 宿主: 小鼠 Monoclonal 4F12A2 unconjugated

anti-Forkhead Box P3 (FOXP3) (AA 191-412) antibody
FOXP3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Forkhead Box P3 (FOXP3) (N-Term) antibody
FOXP3 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔, 马, 犬, 绵羊, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Forkhead Box P3 (FOXP3) (AA 191-412) antibody
FOXP3 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Forkhead Box P3 (FOXP3) (AA 1-431) antibody
FOXP3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Forkhead Box P3 (FOXP3) antibody (APC)
FOXP3 适用: 人, 小鼠 ICFC 宿主: 小鼠 Monoclonal 3G3 APC

anti-Forkhead Box P3 (FOXP3) (AA 283-311) antibody
FOXP3 适用: 人, 小鼠 WB, FACS, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Forkhead Box P3 (FOXP3) antibody
FOXP3 适用: 人, 小鼠, 猴 WB, FACS, IHC, StM 宿主: 小鼠 Monoclonal FXP3-197 unconjugated

anti-Forkhead Box P3 (FOXP3) (C-Term) antibody
FOXP3 适用: 人 WB, ELISA, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
1. Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P. C., Ziegler, S. F., Roncarolo, M. G., Levings, M. K.The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.J. Clin. Invest. 115: 3276-3284, 2005. 2. Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., Saulsbury, F. T., Chance, P. F., Ochs, H. D.The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.Nature Genet. 27: 20-21, 2001. 3. Hong, J., Li, N., Zhang, X., Zheng, B., Zhang, J. Z.Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3.Proc. Nat. Acad. Sci. 102: 6449-6454, 2005.

说明

Antibody can be supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Li, Chen, Xie: "Decreased FOXP3+ and GARP+ Tregs to neoadjuvant chemotherapy associated with favorable prognosis in advanced gastric cancer." in: OncoTargets and therapy, Vol. 9, pp. 3525-33, (2016) (PubMed).

Tao, Zhu, Chen, Wang, Pan, Yu, Zhou, Zhu: "IL-35 improves Treg-mediated immune suppression in atherosclerotic mice." in: Experimental and therapeutic medicine, Vol. 12, Issue 4, pp. 2469-2476, (2016) (PubMed).

Gong, Wang, Yuan, Li, Gu, Zhao, Zhang, Jia, Feng, Liu: "Inhibition of Tumor Growth and Immunomodulatory Effects of Flavonoids and Scutebarbatines of Scutellaria barbata D. Don in Lewis-Bearing C57BL/6 Mice." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 630760, (2015) (PubMed).

Li, Ren, Wang, Gu, Hu, Ren, Hong, Wu, Liu, Li: "T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn's disease." in: International immunopharmacology, Vol. 18, Issue 2, pp. 244-8, (2014) (PubMed).

Wang, Dai, Dong, Sun, Song, Guo, Zhu, Wang, Zhang: "The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokine IL-35 in apolipoprotein E-deficient mice." in: PLoS ONE, Vol. 9, Issue 1, pp. e87787, (2014) (PubMed).

Gai, Li, Song, Lei, Yang: "In situ analysis of FOXP3(+) regulatory T cells and myeloid dendritic cells in human colorectal cancer tissue and tumor-draining lymph node." in: Biomedical reports, Vol. 1, Issue 2, pp. 207-212, (2014) (PubMed).

Hu, Li, Maskey, Xu, Peng, Wang, Li, Yang: "Decreased intratumoral Foxp3 Tregs and increased dendritic cell density by neoadjuvant chemotherapy associated with favorable prognosis in advanced gastric cancer." in: International journal of clinical and experimental pathology, Vol. 7, Issue 8, pp. 4685-94, (2014) (PubMed).

Qiao, Huang, Xu, Zhao, Ran, Shen: "LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn's disease." in: Journal of biomedical science, Vol. 20, pp. 87, (2014) (PubMed).

Fu, Li, Yang, Gai, Jia, Lei, Li: "FOXP3 and TLR4 protein expression are correlated in non-small cell lung cancer: implications for tumor progression and escape." in: Acta histochemica, Vol. 115, Issue 2, pp. 151-7, (2013) (PubMed).

Gai, Song, Li, Lei, Yang: "Potential role of plasmacytoid dendritic cells for FOXP3+ regulatory T cell development in human colorectal cancer and tumor draining lymph node." in: Pathology, research and practice, Vol. 209, Issue 12, pp. 774-8, (2013) (PubMed).
抗原

FOXP3 (Forkhead Box P3 (FOXP3))

别名

FOXP3 (FOXP3 产品)

背景

Synonyms: Forkhead box protein P3,Scurfin,Forkhead box protein P3, C-terminally processed,Forkhead box protein P3 41 kDa form,FOXP3,IPEX,JM2,
Background: FOXP3 (forkhead box P3) is a protein involved in immune system responses. The human FOXP3 genes contain 11 coding exons. Exon-intron boundaries are identical across the coding regions of the mouse and human genes. By genomic sequence analysis, the FOXP3 gene maps to the p arm of the X chromosome (specifically, Xp11.23). A member of the FOX protein family, FOXP3 appears to function as a master regulator in the development and function of regulatory T cells. While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription.
Sequence Similarities: Contains 1 C2H2-type zinc finger.

分子量

78 kDa

基因ID

50943

途径

Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation