FOXO3 抗体 (AA 471-673)
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北京 101111
Quick Overview for FOXO3 抗体 (AA 471-673) (ABIN3042404)
抗原
See all FOXO3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 471-673
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原理
- Anti-FOXO3A Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-FOXO3A Antibody (ABIN3042404). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human FOXO3A recombinant protein (Position: Q471-G673). Human FOXO3A shares 97% amino acid (aa) sequence identity with mouse FOXO3A.
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亚型
- IgG
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anti-Forkhead Box O3 (FOXO3) (pSer253) antibody
FOXO3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (C-Term) antibodyVerified FOXO3 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (pSer318), (pSer321) antibodyFOXO3 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (C-Term) antibodyKO Validated FOXO3 适用: 人 WB, IF, IHC (p), ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (N-Term) antibodyFOXO3 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 绵羊, 兔, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) antibodyFOXO3 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 1E2 unconjugated Recombinant Antibody
anti-Forkhead Box O3 (FOXO3) (N-Term) antibodyFOXO3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (AA 361-460) antibodyFOXO3 适用: 人 ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Forkhead Box O3 (FOXO3) (AA 361-460) antibodyFOXO3 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1F6 unconjugated
anti-Forkhead Box O3 (FOXO3) (AA 224-253) antibodyFOXO3 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- FOXO3 (Forkhead Box O3 (FOXO3))
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别名
- FOXO3
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背景
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Synonyms: Forkhead box protein O3,AF6q21 protein,Forkhead in rhabdomyosarcoma-like 1,FOXO3,FKHRL1, FOXO3A,
Tissue Specificity: Ubiquitous. .
Background: Forkhead box O3, also known as FKHRL1 or FOXO3a, is a human protein encoded by the FOXO3 gene. FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. It is mapped to 6q21. This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and PUMA, or downregulation of anti-apoptotic proteins such as FLIP. In mammals FOXO3 regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life span. In addition, it is thought that FOXO3 is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD.
Sequence Similarities: Contains 1 fork-head DNA-binding domain.
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分子量
- 80-90 kDa
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基因ID
- 2309
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UniProt
- O43524
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途径
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
抗原
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