FMR1 抗体 (N-Term)
Quick Overview for FMR1 抗体 (N-Term) (ABIN3042398)
抗原
See all FMR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 164-200, N-Term
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原理
- Anti-FMRP/FMR1 Antibody Picoband®
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序列
- ENYQLVILSI NEVTSKRAHM LIDMHFRSLR TKLSLIM
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-FMRP/FMR1 Antibody Picoband® (ABIN3042398). Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human FMRP, different from the related mouse and rat sequences by one amino acid.
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亚型
- IgG
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anti-Fragile X Mental Retardation 1 (FMR1) (AA 36-279) antibody
FMR1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 1C6 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 26-279) antibodyFMR1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) antibodyFMR1 适用: 人 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 121-220) antibodyFMR1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2D4 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 1-290) antibodyFMR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 500-600) antibodyFMR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 116-130) antibodyVerified FMR1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 121-220) antibodyFMR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E11 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) antibodyFMR1 适用: 人 IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 4G9 unconjugated
anti-Fragile X Mental Retardation 1 (FMR1) (AA 20-48), (N-Term) antibodyFMR1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20964 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
1. Verkerk AJ, Pieretti M, Sutcliffe JS, Fu YH, Kuhl DP, Pizzuti A, Reiner O, Richards S, Victoria MF, Zhang FP (May 1991). "Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome". Cell 65(5): 905-14. 2. Verheij C, Bakker CE, de Graaff E, Keulemans J, Willemsen R, Verkerk AJ, Galjaard H, Reuser AJ, Hoogeveen AT, Oostra BA (June 1993). "Characterization and localization of the FMR-1 gene product associated with fragile X syndrome". Nature 363 (6431): 722-4. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- FMR1 (Fragile X Mental Retardation 1 (FMR1))
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别名
- FMR1
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背景
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Synonyms: Fragile X mental retardation protein 1;FMRP;Protein FMR-1;FMR1;
Tissue Specificity: Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells. .
Background: FMR1 (fragile X mental retardation 1) is a human gene that codes for a protein called fragile X mentalretardation protein, or FMRP. This protein, most commonly found in the brain, is essential for normal cognitive development and female reproductive function. Mutations of this gene can lead to fragile X syndrome, mental retardation, premature ovarian failure, autism, Parkinson's disease, developmental delays and other cognitive deficits. The protein encoded by this gene binds RNA and is associated with polysomes. Additionally, the encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
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分子量
- 71-73 kDa
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基因ID
- 2332
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UniProt
- Q06787
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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