FLT3LG 抗体 (N-Term)
Quick Overview for FLT3LG 抗体 (N-Term) (ABIN3042394)
抗原
See all FLT3LG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 79-110, N-Term
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原理
- Anti-Flt3 ligand/FLT3LG Antibody Picoband®
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序列
- AQRWMERLKT VAGSKMQGLL ERVNTEIHFV TK
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Flt3 ligand/FLT3LG Antibody Picoband® (ABIN3042394). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Flt-3ligand, different from the related mouse sequence by four amino acids.
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亚型
- IgG
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anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-189) antibody
FLT3LG 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-136) antibodyFLT3LG 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4C4 unconjugated
anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 61-160) antibodyFLT3LG 适用: 人, 小鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 83-182) antibodyFLT3LG 适用: 人 WB 宿主: 小鼠 Monoclonal D13 unconjugated
anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-184) antibodyFLT3LG 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 1-235) antibodyFLT3LG 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (C-Term) antibodyFLT3LG 适用: 人, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-181) antibodyFLT3LG 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 8D10 unconjugated
anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (C-Term) antibodyFLT3LG 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) antibodyFLT3LG 适用: 人 FACS 宿主: 兔 Chimeric unconjugated Fc fragment
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Hannum, C., Culpepper, J., Campbell, D., McClanahan, T., Zurawski, S., Bazan, J. F., Kastelein, R., Hudak, S., Wagner, J., Mattson, J., Luh, J., Duda, G., and 14 others. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 368: 643-648, 1994. 2. Lyman, S. D., James, L., Vanden Bos, T., de Vries, P., Brasel, K., Gliniak, B., Hollingsworth, L. T., Picha, K. S., McKenna, H. J., Splett, R. R., Fletcher, F. A., Maraskovsky, E., Farrah, T., Foxworthe, D., Williams, D. E., Beckmann, M. P. Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell 75: 1157-1167, 1993. 3. Sathaliyawala, T., O'Gorman, W. E., Greter, M., Bogunovic, M., Konjufca, V., Hou, Z. E., Nolan, G. P., Miller, M. J., Merad, M., Reizis, B. Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity 33: 597-606, 2010. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))
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别名
- FLT3LG
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背景
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Synonyms: Fms-related tyrosine kinase 3 ligand,Flt3 ligand,Flt3L,SL cytokine,FLT3LG,
Tissue Specificity: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. .
Background: FLT3LG (FMS-Related Tyrosine Kinase 3 Ligand) also called FLT3 LIGAND, FL or FLT3L, is a protein which in humans is encoded by the FLT3LG gene. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8-positive classical DCs and their CD103-positive tissue counterparts. Flt3 ligand (FL) is a hematopoietic four helical bundlecytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. Lyman et al. (1993) found that Flt3 ligand stimulated proliferation of hematopoietic progenitor cells isolated from mouse fetal liver or adult mouse bone marrow. Hannum et al. (1994) concluded that FL enhances the response of stem and primitive progenitor cells to other growth factors to generate all myeloid lineages except erythroid cells. Assays of C-terminally truncated FL proteins confirmed that the N-terminal half conferred FL activity. Depletion of the Pi3k -Mtor negative regulator Pten facilitated Flt3l-driven DC development in culture.
Sequence Similarities: Belongs to the heparin-binding growth factors family.
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分子量
- 26 kDa
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基因ID
- 2323
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UniProt
- P49771
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途径
- RTK signaling
抗原
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