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Menin 抗体 (AA 301-615)

This anti-Menin antibody is a 兔多克隆 antibody detecting Menin in WB. Suitable for 人和小鼠.

Anti- Menin Picoband antibody, Western blotting All lanes: Anti Menin at 0. (Menin 抗体 (AA 301-615))

Anti- Menin Picoband antibody, Western blotting All lanes: Anti Menin at 0. (Menin 抗体 (AA 301-615))

2 images

产品编号 ABIN3042359

发货至: 中国

Datasheet as PDF

Quick Overview for Menin 抗体 (AA 301-615) (ABIN3042359)

抗原

See all Menin (MEN1) 抗体

Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

适用

82
36
30
4
3
3
2
1
1
1

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

43
6
6
5
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

This Menin antibody is un-conjugated

应用范围

55
39
28
14
13
13
10
9
7
3
2
1
1
1

Western Blotting (WB)

Discover our top product MEN1 Primary Antibody

抗原表位
15

7

7

6

6

6

4

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 301-615

原理

Anti-Menin/MEN1 Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Menin/MEN1 Antibody Picoband® (ABIN3042359). Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Menin recombinant protein (Position: P301-L615). Human Menin shares 93% and 94% amino acid (aa) sequence identity with mouse and rat Menin, respectively.

亚型

IgG
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 392-554) antibody
MEN1 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7D3E10 unconjugated

anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 501-615) antibody
MEN1 适用: 人, 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 219-395) antibody
MEN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 1-575) antibody
MEN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 1-575) antibody
MEN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Multiple Endocrine Neoplasia 1 (MEN1) (Internal Region) antibody
MEN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 1-615) antibody
MEN1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 506-615) antibody
MEN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Multiple Endocrine Neoplasia 1 (MEN1) (C-Term) antibody
MEN1 适用: 人, 小鼠 WB, ChIP-seq, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Multiple Endocrine Neoplasia 1 (MEN1) (Internal Region) antibody
MEN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Mouse
1. Canaff, L., Vanbellinghen, J.-F., Kaji, H., Goltzman, D., Hendy, G. N. Impaired transforming growth factor-beta (TGF-beta) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1). J. Biol. Chem. 287: 8584-8597, 2012. 2. Kaji, H., Canaff, L., Lebrun, J.-J., Goltzman, D., Hendy, G. N. Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. Proc. Nat. Acad. Sci. 98: 3837-3842, 2001. 3. Zablewska, B., Bylund, L., Mandic, S. A., Fromaget, M., Gaudray, P., Weber, G. Transcription regulation of the multiple endocrine neoplasia type 1 gene in human and mouse. J. Clin. Endocr. Metab. 88: 3845-3851, 2003.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
抗原

Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

别名

MEN1

背景

Synonyms: Menin,MEN1,SCG2,
Tissue Specificity: Ubiquitous.
Background: The MEN1 gene encodes menin, a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling. It is mapped to 11q13.1. MEN1 is considered to act as a tumor suppressor gene. It has been found that that MEN1 inactivation by antisense RNA antagonizes transforming growth factor-beta-mediated cell growth inhibition. Overexpression of MEN1 in an inducible cell culture system downregulated the proximal promoter. In vitro studies have shown that MEN1 is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. What's more, MEN1 was essential to maintain MLL-associated myeloid transformation.

分子量

68 kDa

基因ID

4221

UniProt

O00255

途径

Chromatin Binding, Positive Regulation of Endopeptidase Activity

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