PKC iota 抗体 (AA 21-214)
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Quick Overview for PKC iota 抗体 (AA 21-214) (ABIN3032379)
抗原
See all PKC iota (PRKCI) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-214
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纯化方法
- Antigen affinity
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免疫原
- Human partial recombinant protein (AA 21-214) was used as the immunogen for this PKC iota antibody.
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亚型
- IgG
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anti-Protein Kinase C, iota (PRKCI) (AA 375-596) antibody
PRKCI 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, iota (PRKCI) (AA 1-587) antibodyPRKCI 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 1G11 unconjugated
anti-Protein Kinase C, iota (PRKCI) (AA 21-214) antibodyPRKCI 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, iota (PRKCI) (AA 1-100) antibodyPRKCI 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A10 unconjugated
anti-Protein Kinase C, iota (PRKCI) (AA 176-207), (N-Term) antibodyPRKCI 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01026 unconjugated
anti-Protein Kinase C, iota (PRKCI) (Internal Region) antibodyPRKCI 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, iota (PRKCI) (AA 215-264) antibodyPRKCI 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, iota (PRKCI) (Middle Region) antibodyPRKCI 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the PKC iota antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the PKC iota antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))
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别名
- PKC iota
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背景
- Protein kinase C iota, also called PKCI, is an enzyme that in humans is encoded by the PRKCI gene. This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where it phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. PRKCI is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. It is also a hedgehog target gene that forms a positive feedback loop with GLI and exists at increased levels in basal cell carcinomas.
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基因ID
- 5584
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途径
- Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, Tube Formation
抗原
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