CASP5 抗体 (Center)
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Quick Overview for CASP5 抗体 (Center) (ABIN303202)
抗原
See all CASP5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide corresponding to 14 amino acid peptide from the center of human Caspase-5.
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应用备注
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Immunohistochemistry on Paraffin Sections (5 μg/mL). Immunocytochemistry. Western Blot (0.5-1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate Buffered Saline PBS, containing 0.02 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer. Dilute only prior to immediate use.
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- CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
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别名
- Caspase-5
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背景
- Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-5 can interact with caspase-1, both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1b. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-g.Synonyms: CASP-5, CASP5, ICE(rel)-III, ICH-3 protease, ICH3, TY protease
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基因ID
- 838
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NCBI登录号
- NP_001129581
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UniProt
- P51878
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途径
- Inflammasome
抗原
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