PPARA 抗体 (AA 1-18)
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Quick Overview for PPARA 抗体 (AA 1-18) (ABIN303185)
抗原
See all PPARA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-18
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特异性
- ,Species:Chimpanzee, Human, Monkey and Mouse.
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纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide corresponding to Amino Acids 1-18 of mouse PPAR alpha.
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anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 301-400) antibody
PPARA 适用: 人, 小鼠, 大鼠, 小鸡 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 61-170) antibodyPPARA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 1-120) antibodyPPARA 适用: 人, 猴 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 5D10C3 unconjugated
anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 1-468) antibodyPPARA 适用: 人, 小鼠 WB, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 1331CT894-186-143 unconjugated
anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (N-Term) antibodyKO Validated PPARA 适用: 人 WB, IP, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (AA 1-120) antibodyPPARA 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5D10E10 unconjugated
anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (C-Term) antibodyPPARA 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, Pig, 山羊, 豚鼠, 兔, 绵羊, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (N-Term) antibodyPPARA 适用: 人, 小鼠 WB, ELISA, IHC, FACS, IF, FM 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (pSer12) antibodyPPARA 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor alpha (PPARA) (N-Term) antibodyPPARA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Immunohistochemistry on Paraffin Sections (20 μg/mL). Western Blot (1/500-1/2000). ELISA (1/8000-1/32000).
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限制
- 仅限研究用
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浓度
- 1.7 mg/mL
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缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody undiluted (in aliquots) at-20 °C. Dilute only prior to immediate use.
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- PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))
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别名
- PPAR-alpha
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背景
- Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.Synonyms: NR1C1, Nuclear receptor subfamily 1 group C member 1, PPAR, PPARA, Peroxisome proliferator-activated receptor alpha
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基因ID
- 19013
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NCBI登录号
- NP_001106889
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UniProt
- P23204
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Hepatitis C
抗原
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