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FOXO3 抗体 (AA 471-673)

This anti-FOXO3 antibody is a 兔 多克隆 antibody detecting FOXO3 in WB 和 IHC (p). Suitable for 人 和 大鼠.
产品编号 ABIN3030992
发货至: 中国

Quick Overview for FOXO3 抗体 (AA 471-673) (ABIN3030992)

抗原

See all FOXO3 抗体
FOXO3 (Forkhead Box O3 (FOXO3))

适用

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人, 大鼠

宿主

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克隆类型

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多克隆

标记

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This FOXO3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    AA 471-673

    纯化方法

    Antigen affinity

    免疫原

    Human partial recombinant protein (AA 471-673) was used as the immunogen for this FOXO3A antibody.

    亚型

    IgG
  • 应用备注

    The stated application concentrations are suggested starting amounts. Titration of the FOXO3A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

    限制

    仅限研究用
  • 缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    -20 °C

    储存方法

    After reconstitution, the FOXO3A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原

    FOXO3 (Forkhead Box O3 (FOXO3))

    别名

    FOXO3A

    背景

    Forkhead box O3, also known as FKHRL1 or FOXO3A, is a human protein encoded by the FOXO3 gene. FOXO3A belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. It is mapped to 6q21. This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and< a href=../search_result.php?search_txt=puma>PUMA, or downregulation of anti-apoptotic proteins such as FLIP. In mammals FOXO3A regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life span. In addition, it is thought that FOXO3A is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD.

    基因ID

    2309

    途径

    Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
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