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Beclin 1 抗体 (AA 1-354)

This anti-Beclin 1 antibody is a 兔 多克隆 antibody detecting Beclin 1 in WB 和 IHC (p). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN3030155
发货至: 中国

Quick Overview for Beclin 1 抗体 (AA 1-354) (ABIN3030155)

抗原

See all Beclin 1 (BECN1) 抗体
Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This Beclin 1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    AA 1-354

    纯化方法

    Antigen affinity

    免疫原

    Human partial recombinant protein (AA 1-354) was used as the immunogen for this Beclin 1 antibody.

    亚型

    IgG
  • 应用备注

    Titration of the Beclin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

    限制

    仅限研究用
  • 缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    -20 °C

    储存方法

    After reconstitution, the Beclin 1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原

    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

    别名

    Beclin 1

    背景

    Beclin 1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin 1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of the protein in the hippocampus of the affected which causes diminished autophagy which in turn results in increased neuronal cell death. It has been found that Beclin 1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.

    基因ID

    8678

    途径

    Autophagy
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