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Vitamin D Receptor 抗体 (C-Term)

This anti-Vitamin D Receptor antibody is a 兔 多克隆 antibody detecting Vitamin D Receptor in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN3029598
发货至: 中国

Quick Overview for Vitamin D Receptor 抗体 (C-Term) (ABIN3029598)

抗原

See all Vitamin D Receptor (VDR) 抗体
Vitamin D Receptor (VDR)

适用

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人, 小鼠, 大鼠

宿主

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  • 1
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克隆类型

  • 96
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多克隆

标记

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This Vitamin D Receptor antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    C-Term

    纯化方法

    Antigen affinity

    免疫原

    An amino acid sequence from the C-terminus of human Vitamin D Receptor (DLRSLNEEHSKQYRCL) was used as the immunogen for this VDR antibody.

    亚型

    IgG
  • 应用备注

    The stated application concentrations are suggested starting amounts. Titration of the VDR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

    限制

    仅限研究用
  • 缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    -20 °C

    储存方法

    After reconstitution, the VDR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原

    Vitamin D Receptor (VDR)

    别名

    VDR (Vitamin D Receptor)

    物质类

    Chemical

    背景

    Vitamin D Receptor, also known as Vitamin D Hormone Receptor, is a member of the nuclear receptor family of transcription factors. Labuda et al.(1991) assigned the VDR gene to 12q12-q14 by in situ hybridization. Using mutation analysis, Jurutka et al.(2000) characterized arg18/arg22, VDR residues immediately N-terminal of the first DNA-binding zinc finger, as vital for contact with the general transcription factor IIB(TFIIB). A natural polymorphic variant of the receptor, termed F/M4(missing a FokI restriction site), which lacks only the first 3 amino acids(including glu2), interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length(f/M1) receptor. Shah et al.(2006) stated that the signaling and oncogenic activity of beta-catenin(CTNNB1) can be repressed by activation of VDR. Conversely, high levels of beta-catenin can potentiate the transcriptional activity of 1,25-dihydroxyvitamin D3.

    UniProt

    P11473

    途径

    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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