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VCP 抗体 (AA 732-760)

This anti-VCP antibody is a 兔 多克隆 antibody detecting VCP in WB, IHC (p) 和 IHC (fro). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN3029568
发货至: 中国

Quick Overview for VCP 抗体 (AA 732-760) (ABIN3029568)

抗原

See all VCP 抗体
VCP (Valosin Containing Protein (VCP))

适用

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人, 小鼠, 大鼠

宿主

  • 83
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克隆类型

  • 74
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多克隆

标记

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This VCP antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 732-760

    纯化方法

    Antigen affinity

    免疫原

    Amino acids 732-760 (RRDHFEEAMRFARRSVSDNDIRKYEMFAQ) were used as the immunogen for the VCP antibody (100% homologous in human, mouse and rat).

    亚型

    IgG
  • 应用备注

    The stated application concentrations are suggested starting amounts. Titration of the VCP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

    限制

    仅限研究用
  • 缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    -20 °C

    储存方法

    After reconstitution, the VCP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原

    VCP (Valosin Containing Protein (VCP))

    别名

    VCP

    背景

    Valosin-containing protein, also called Cdc48, is an enzyme that in humans is encoded by the VCP gene. It is a member of the AAA+(ATPase associated with various activities) protein family. The gene maps to chromosome 9p13.3. It is necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. It is involved in the formation of the transitional endoplasmic reticulum. This gene plays a role in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP is also involved in DNA damage response: recruited to double-strand breaks(DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites.

    UniProt

    P55072

    途径

    ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway
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