c-MYC 抗体 (AA 257-439)
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Quick Overview for c-MYC 抗体 (AA 257-439) (ABIN3029536)
抗原
See all c-MYC (MYC) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 257-439
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纯化方法
- Antigen affinity
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免疫原
- Human partial recombinant protein (AA 257-439) was used as the immunogen for this c-Myc antibody.
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亚型
- IgG
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应用备注
- The stated application concentrations are suggested starting points. Titration of the c-Myc antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the c-Myc antibody can be stored for up to one month at 4 °C. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.
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- c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
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别名
- C-Myc
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背景
- C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. It elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of the protein is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.
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基因ID
- 4609
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途径
- p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect
抗原
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