LAMP3 抗体 (full length)
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北京 101111
Quick Overview for LAMP3 抗体 (full length) (ABIN3023870)
抗原
See all LAMP3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- LAMP-3 Antibody / CD63
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产品特性
- This mAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63/LAMP3 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. It is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
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纯化方法
- Protein G affinity chromatography
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免疫原
- Recombinant human full-length protein was used as the immunogen for the CD63 / LAMP-3 antibody.
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亚型
- IgG2a, kappa
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anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) (AA 222-381) antibody
LAMP3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) (AA 218-381) antibodyLAMP3 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 7E12C5 unconjugated
anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) antibodyLAMP3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) antibodyLAMP3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) (Internal Region) antibodyLAMP3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) (AA 28-224) antibodyLAMP3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) (AA 8-38) antibodyLAMP3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) (AA 301-416) antibodyLAMP3 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) (AA 1-416) antibodyLAMP3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 3 (LAMP3) (AA 36-85) antibodyLAMP3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Optimal dilution of the LAMP-3 antibody should be determined by the researcher.
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the LAMP-3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))
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别名
- LAMP-3
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背景
- This mAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63/LAMP-3. Its epitope is different from that of mAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63/LAMP-3 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. It is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP-3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
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UniProt
- P08962
抗原
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