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HMGCR 抗体 (AA 629-888)

Name: HMGCR 抗体 (AA 629-888)
Brand: antibodies-online
SKU: ABIN3022294
Availability: OutOfStock

This anti-HMGCR antibody is a 兔多克隆 antibody detecting HMGCR in WB, IHC 和 IF. Suitable for 人. This Primary Antibody has been cited in 2+ publications.

Immunohistochemistry of paraffin-embedded human small intestine using HMGCR antibody (ABIN3022293, ABIN3022294, ABIN3022295, ABIN1513022 and ABIN6218714) at dilution of 1:200 (40x lens). (HMGCR 抗体 (AA 629-888))

IHC

Immunofluorescence analysis of NIH-3T3 cells using HMGCR Rabbit pAb (ABIN3022293, ABIN3022294, ABIN3022295, ABIN1513022 and ABIN6218714) at dilution of 1:100 (40x lens). (HMGCR 抗体 (AA 629-888))

Western blot analysis of extracts of various cell lines, using HMGCR antibody. (HMGCR 抗体 (AA 629-888))

Immunofluorescence analysis of A549 cell using HMGCR antibody. (HMGCR 抗体 (AA 629-888))

Western blot analysis of extracts of Mouse spleen, using HMGCR Rabbit pAb (ABIN3022293, ABIN3022294, ABIN3022295, ABIN1513022 and ABIN6218714) at 1:1000 dilution. (HMGCR 抗体 (AA 629-888))

Immunohistochemistry of paraffin-embedded human uterine cancer using HMGCR antibody (ABIN3022293, ABIN3022294, ABIN3022295, ABIN1513022 and ABIN6218714) at dilution of 1:200 (40x lens). (HMGCR 抗体 (AA 629-888))

IHC

Western blot analysis of extracts of Rat brain, using HMGCR Rabbit pAb (ABIN3022293, ABIN3022294, ABIN3022295, ABIN1513022 and ABIN6218714) at 1:1000 dilution. (HMGCR 抗体 (AA 629-888))

Immunofluorescence analysis of C6 cells using HMGCR Rabbit pAb (ABIN3022293, ABIN3022294, ABIN3022295, ABIN1513022 and ABIN6218714) at dilution of 1:100 (40x lens). (HMGCR 抗体 (AA 629-888))

Immunofluorescence analysis of U-2 OS cells using HMGCR Rabbit pAb (ABIN3022293, ABIN3022294, ABIN3022295, ABIN1513022 and ABIN6218714) at dilution of 1:100 (40x lens). (HMGCR 抗体 (AA 629-888))

9 images

(2 references)

产品编号 ABIN3022294

发货至: 中国

Quick Overview for HMGCR 抗体 (AA 629-888) (ABIN3022294)

抗原

See all HMGCR 抗体

HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

适用

人

宿主

兔

克隆类型

多克隆

标记

This HMGCR antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

抗原表位
16

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6

3

1

1

1

1

1

1

1
AA 629-888

序列

ARLQKLHTSI AGRNLYIRFQ SRSGDAMGMN MISKGTEKAL SKLHEYFPEM QILAVSGNYC TDKKPAAINW IEGRGKSVVC EAVIPAKVVR EVLKTTTEAM IEVNINKNLV GSAMAGSIGG YNAHAANIVT AIYIACGQDA AQNVGSSNCI TLMEASGPTN EDLYISCTMP SIEIGTVGGG TNLLPQQACL QMLGVQGACK DNPGENARQL ARIVCGTVMA GELSLMAALA AGHLVKSHMI HNRSKINLQD LQGACTKKTA

交叉反应

人, 小鼠, 大鼠

产品特性

Polyclonal Antibodies

纯化方法

Affinity purification

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 629-888 of human HMGCR (NP_000850.1).

亚型

IgG
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 638-887) antibody
HMGCR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (pSer872) antibody
HMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 588-887) antibody
HMGCR 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (N-Term) antibody
HMGCR 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 251-350) antibody
HMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (Internal Region) antibody
Verified HMGCR 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated

anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 1-835) antibody
HMGCR 适用: 人 IP 宿主: 兔 Polyclonal unconjugated

anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) antibody
HMGCR 适用: 人, 大鼠, 小鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (pSer872) antibody (Biotin)
HMGCR 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal Biotin

anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (pSer872) antibody (AbBy Fluor® 750)
HMGCR 适用: 人, 大鼠, 小鼠 WB, FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 750

应用备注

WB,1:1000 - 1:4000,IHC,1:50 - 1:100,IF,1:50 - 1:200

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze / thaw cycles

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Cheng, Zhu, Han, Zhang, Cui, Shen, Zhang, Yan, Prochownik, Li: "MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice." in: Cell death & disease, Vol. 8, Issue 7, pp. e2916, (2018) (PubMed).

Li, Xia, Xiong, Wang, Yan: "Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5635-5640, (2017) (PubMed).
抗原

HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

别名

HMGCR

背景

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,HMGCR,LDLCQ3,HMGCR,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,AMPK Signaling Pathway,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,HMGCR

分子量

92 kDa/97 kDa/99 kDa

基因ID

3156

UniProt

P04035

途径

AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha