Endoglin 抗体 (FITC)
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- 抗原 See all Endoglin (ENG) 抗体
- Endoglin (ENG)
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适用
- 人, Pig
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Endoglin antibody is conjugated to FITC
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应用范围
- Flow Cytometry (FACS)
- 特异性
- This antibody recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.
- 交叉反应 (详细)
- Species reactivity (tested):Human, Porcine.
- 产品特性
- Synonyms: ENG, END, HHT1, ORW, ORW1
- 免疫原
- Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA
- 克隆位点
- MEM-229
- 亚型
- IgG2a
- Top Product
- Discover our top product ENG Primary Antibody
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- 应用备注
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Flow Cytometry analysis of human blood cells using 20 l reagent / 100 l of whole bloodor 10^6 cells in a suspension.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
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Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- Endoglin (ENG)
- 别名
- CD105 / Endoglin (ENG 产品)
- 背景
- CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbR-2 as a receptor for TGFb-1 and TGFb-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFb-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.Synonyms: END, ENG, HHT1, ORW, ORW1
- UniProt
- P17813
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