c-MYC 抗体 (pThr58)
Our Local Distributor
北京 101111
Quick Overview for c-MYC 抗体 (pThr58) (ABIN3019539)
抗原
See all c-MYC (MYC) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pThr58
-
交叉反应
- 人, 小鼠, 大鼠
-
产品特性
- Phosphorylated Antibodies
-
纯化方法
- Affinity purification
-
免疫原
- A phospho specific peptide corresponding to residues surrounding T58 of human MYC
-
亚型
- IgG
-
-
-
-
应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
-
限制
- 仅限研究用
-
-
-
缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
-
别名
- MYC
-
背景
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.,MRTL,MYCC,bHLHe39,c-Myc,MYC,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Tumor biomarkers,Signal Transduction,MAPK-Erk Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell differentiation,G1/S Checkpoint,Hedgehog Signaling Pathway,Notch Signaling Pathway,Endocrine & Metabolism,Warburg Effect,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,Stem Cells,Protein phosphorylation,MYC
-
分子量
- 48 kDa/50 kDa
-
基因ID
- 4609
-
UniProt
- P01106
-
途径
- p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect
抗原
-