IKZF1 抗体 (AA 1-270)
Quick Overview for IKZF1 抗体 (AA 1-270) (ABIN3015622)
抗原
See all IKZF1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-270
-
序列
- MDADEGQDMS QVSGKESPPV SDTPDEGDEP MPIPEDLSTT SGGQQSSKSD RVVASNVKVE TQSDEENGRA CEMNGEECAE DLRMLDASGE KMNGSHRDQG SSALSGVGGI RLPNGKLKCD ICGIICIGPN VLMVHKRSHT GERPFQCNQC GASFTQKGNL LRHIKLHSGE KPFKCHLCNY ACRRRDALTG HLRTHSVIKE ETNHSEMAED LCKIGSERSL VLDRLASNVA KRKSSMPQKF LGDKGLSDTP YDSSASYEKE NEMMKSHVMD
-
交叉反应
- 人, 小鼠, 大鼠
-
产品特性
- Polyclonal Antibodies
-
免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human Ikaros (NP_001207694.1).
-
亚型
- IgG
-
-
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) (AA 1-265) antibody
IKZF1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) (AA 415-444), (C-Term) antibodyIKZF1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24656 unconjugated
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) (C-Term) antibody (PE)IKZF1 适用: 人, 小鼠 ICFC 宿主: 小鼠 Monoclonal 4E9 PE
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) antibodyIKZF1 适用: 人 WB, IF, ChIP 宿主: 兔 Monoclonal unconjugated
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) (AA 428-459), (C-Term) antibodyIKZF1 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) (Middle Region) antibodyIKZF1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) (Internal Region) antibodyVerified IKZF1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) (AA 1-477) antibodyIKZF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) (N-Term) antibodyIKZF1 适用: 小鼠 WB, ChIP, ChIP-seq 宿主: 小鼠 Monoclonal 2A9 unconjugated
anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) antibodyIKZF1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200,ChIP,1:50 - 1:200
-
限制
- 仅限研究用
-
-
-
缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
-
别名
- IKZF1
-
背景
- This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).,IKZF1,CVID13,Hs.54452,IK1,IKAROS,LYF1,LyF-1,PPP1R92,PRO0758,ZNFN1A1,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,IKZF1
-
分子量
- 24-31 kDa/41-57 kDa
-
基因ID
- 10320
-
UniProt
- Q13422
-
途径
- Production of Molecular Mediator of Immune Response
抗原
-
