Perforin 1 抗体
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北京 101111
Quick Overview for Perforin 1 抗体 (ABIN285909)
抗原
See all Perforin 1 (PRF1) 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 小鼠, 大鼠
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交叉反应 (详细)
- Reacts with both rat and mouse perforin. Cross-reactivity to perforin of other species has not been tested.
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纯化方法
- purified
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免疫原
- Perforin antibody was raised in rabbit using E. coli-expressed rat perforin as the immunogen.
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应用备注
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WB: 1:1,000
Optimal conditions should be determined by the investigator. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitue in distilled water.
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浓度
- Lot specific
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缓冲液
- Supplied as a lyophilized Potein A purified rabbit IgG with 0.1 % NaN3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.
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- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
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别名
- Perforin
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背景
- Perforin-1 is a protein that in humans is encoded by the PRF1 gene. Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria.
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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