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LOXL2 抗体

Name: LOXL2 抗体
Brand: antibodies-online
SKU: ABIN2856034
Availability: OutOfStock

This anti-LOXL2 antibody is a 兔多克隆 antibody detecting LOXL2 in WB, IHC, ELISA, ICC, IHC (p) 和 IF. Suitable for 人. This Primary Antibody has been cited in 5+ publications.

WB Image Non-transfected (–) and transfected (+) 293T whole cell extracts (30 μg) were separated by 7. (LOXL2 抗体)

IHC-P Image LOXL2 antibody detects LOXL2 protein at cytosol on human ovarian carcinoma by immunohistochemical analysis. (LOXL2 抗体)

IHC

IHC-P Image LOXL2 antibody detects LOXL2 protein at cytoplasm and membrane in human cervical carcinoma by immunohistochemical analysis. (LOXL2 抗体)

IHC

WB Image LOXL2 antibody detects LOXL2 protein by western blot analysis. (LOXL2 抗体)

LOX/L expression in experimental lung fibrosis. (LOXL2 抗体)

IHC (p)

LOX/L expression in human IPF lungs. (LOXL2 抗体)

IHC (p)

Expression of HIF-1α and LOXL2 correlates with vasculogenic mimicry (VM) and poor prognosis in HCC samples. (LOXL2 抗体)

IHC

HIF-1α promotes LOXL2 expression was demonstrated by downregulation of HIF-1α with CoCl2 treatment in HepG2 and Bel7402 cells. (LOXL2 抗体)

8 images

(5 references)

产品编号 ABIN2856034

发货至: 中国

Quick Overview for LOXL2 抗体 (ABIN2856034)

抗原

See all LOXL2 抗体

LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This LOXL2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

质量等级

KO Validated

特异性

Mouse reactivity has been validated by IHC-P only, not yet been tested by other applications.

交叉反应

人, 小鼠

产品特性

Rabbit Polyclonal antibody to LOXL2 (lysyl oxidase-like 2)
LOXL2 antibody

纯化方法

Purified by antigen-affinity chromatography.

免疫原

Recombinant protein encompassing a sequence within the center region of human LOXL2. The exact sequence is proprietary.

亚型

IgG
anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 544-751) antibody
LOXL2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Lysyl Oxidase-Like 2 (LOXL2) antibody
LOXL2 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Monoclonal 2E5 unconjugated Recombinant Antibody

anti-Lysyl Oxidase-Like 2 (LOXL2) (Internal Region) antibody
LOXL2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 675-773) antibody
LOXL2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5D2 unconjugated

anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 53-160) antibody
LOXL2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 27-121) antibody
LOXL2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 675-773) antibody
LOXL2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 505-774) antibody
LOXL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 553-761) antibody
LOXL2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Lysyl Oxidase-Like 2 (LOXL2) (AA 434-546) antibody
LOXL2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

说明

Positive Control: U87-MG , SK-N-SH , SK-N-AS , 293T transfected with LOXL2
Validation: KO/KD, Orthogonal, Overexpression

限制

仅限研究用
状态

Liquid

浓度

0.86 mg/mL

缓冲液

1XPBS, 20 % Glycerol ( pH 7), 0.025 % ProClin 300

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Cao, Lin, Zhi, Lazare, Meng, Wu, Gao, Wei, Wu: "LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype." in: Frontiers in oncology, Vol. 10, pp. 284, (2020) (PubMed).

Mahjour, Dambal, Shrestha, Singh, Noonan, Kantarci, Trackman: "Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB." in: Oncogenesis, Vol. 8, Issue 5, pp. 34, (2019) (PubMed).

Wang, Zhao, Zhu, Liu, Liang, Liu, Zhang, Dong, Sun: "HIF-1α promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 60, (2018) (PubMed).

Aumiller, Strobel, Romeike, Schuler, Stierstorfer, Kreuz: "Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis." in: Scientific reports, Vol. 7, Issue 1, pp. 149, (2018) (PubMed).

Bais, Kukuruzinska, Trackman: "Orthotopic non-metastatic and metastatic oral cancer mouse models." in: Oral oncology, Vol. 51, Issue 5, pp. 476-82, (2015) (PubMed).
抗原

LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))

别名

lysyl oxidase like 2

背景

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Cellular Localization: Secreted , extracellular space

分子量

87 kDa

基因ID

4017

UniProt

Q9Y4K0

途径

Chromatin Binding