HPD 抗体
Quick Overview for HPD 抗体 (ABIN2855744)
抗原
See all HPD 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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交叉反应
- 人
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产品特性
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Rabbit polyclonal antibody to HPD (4-hydroxyphenylpyruvate dioxygenase)
HPD antibody [N1C2] -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human HPD. The exact sequence is proprietary.
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亚型
- IgG
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应用备注
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: HepG2
Validation: KO/KD
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis." in: Cell death & disease, Vol. 10, Issue 7, pp. 525, (2020) (PubMed).
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: "4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis." in: Cell death & disease, Vol. 10, Issue 7, pp. 525, (2020) (PubMed).
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- HPD (4-Hydroxyphenylpyruvate Dioxygenase (HPD))
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别名
- 4-hydroxyphenylpyruvate dioxygenase
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背景
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The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.
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分子量
- 45 kDa
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基因ID
- 3242
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UniProt
- P32754
抗原
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