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PLAT 抗体

This anti-PLAT antibody is a 兔 多克隆 antibody detecting PLAT in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2855635
发货至: 中国

Quick Overview for PLAT 抗体 (ABIN2855635)

抗原

See all PLAT 抗体
PLAT (Plasminogen Activator, Tissue (PLAT))

适用

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宿主

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克隆类型

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多克隆

标记

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This PLAT antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 交叉反应

    人, 小鼠, 大鼠

    产品特性

    Rabbit Polyclonal antibody to tPA (plasminogen activator, tissue)
    tPA antibody

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human tPA. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: 293T , Neuro2A , PC-12 , human plasma

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.15 mg/mL

    缓冲液

    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Lyubenov, Shi, Zhao, Yang, Lei, Mammadova-Bach, de Chiara, Semeraro, Landini, Romagnani, Vörg, Devarapu, Welz, Kiessig, Anders: "Intravenous Glu-plasminogen attenuates cholesterol crystal embolism-induced thrombotic angiopathy, acute kidney injury and kidney infarction." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, (2022) (PubMed).

  • 抗原

    PLAT (Plasminogen Activator, Tissue (PLAT))

    别名

    plasminogen activator, tissue type

    背景

    This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

    Cellular Localization: Secreted , extracellular space

    分子量

    63 kDa

    基因ID

    5327

    UniProt

    P00750

    途径

    Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome
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