c-MYC 抗体 (Center)
(5 references)Our Local Distributor
北京 101111
Quick Overview for c-MYC 抗体 (Center) (ABIN2855631)
Key Features
- High quality c-MYC Primary Antibody for the detection of MYC.
- Reliable product with high standard validation data
抗原
See all c-MYC (MYC) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Center
-
交叉反应
- Chimpanzee
-
交叉反应 （详细）
- Chimpanzee (100 %)
-
产品特性
-
Rabbit Polyclonal antibody to c-Myc (v-myc myelocytomatosis viral oncogene homolog (avian))
c-Myc antibody -
纯化方法
- Purified by antigen-affinity chromatography.
-
免疫原
- Recombinant protein encompassing a sequence within the center region of human c-Myc. The exact sequence is proprietary.
-
亚型
- IgG
-
Product Specific Information
-
- What can the c-MYC Antibody ABIN2855631 be used for?
- This polyclonal c-MYC Antibody detects c-MYC. The c-MYC Antibody has been validated for various applications and can be used for the detection of c-MYC and derivatives by Western Blotting, Immunofluorescence, Immunoprecipitation, Immunocytochemistry, Chromatin Immunoprecipitation.
- What validation data is available for this c-MYC Antibody?
- The Primary Antibody is referenced in 5 publications and is characterized by a proven, very high reliability. It has currently 8 product images that show its performance in a variety of applications. The product is currently available in 100 μL quantity. c-MYC Antibody for the detection of c-MYC and derivatives.
- What is the function of c-MYC?
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].
-
-
anti-Myc Proto-Oncogene protein (MYC) (AA 330-439) antibody
MYC 适用: 人 WB, IF, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-Myc Proto-Oncogene protein (MYC) (AA 31-80) antibodyMYC 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myc Proto-Oncogene protein (MYC) (pSer62) antibodyMYC 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myc Proto-Oncogene protein (MYC) (pThr58) antibodyMYC 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myc Proto-Oncogene protein (MYC) (pSer62) antibodyMYC 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myc Proto-Oncogene protein (MYC) (AA 360-440) antibodyMYC 适用: 人, 小鼠, 大鼠 WB, IF, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myc Proto-Oncogene protein (MYC) (AA 101-200) antibodyMYC 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myc Proto-Oncogene protein (MYC) (N-Term) antibodyMYC 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myc Proto-Oncogene protein (MYC) antibodyMYC 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7E10 unconjugated
anti-Myc Proto-Oncogene protein (MYC) (pThr58) antibodyMYC 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 24GB230 unconjugated Recombinant Antibody
-
-
应用备注
- Suggested dilution Reference ChIP assay Assay-dependent dilution ICC/IF 1:100-1:1000* Immunoprecipitation 1:100-1:500* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceChIP assayAssay-dependent dilution ICC/IF1:100-1:1000* Immunoprecipitation1:100-1:500* Western blot1:500-1:3000*
-
说明
-
Positive Control: 293T , NIH-3T3 , Raw264.7 , HeLa , HeLa nuclear extract
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- 1XPBS, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
-
储存液
- Thimerosal (Merthiolate)
-
注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
-
-
: "ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis." in: Oncogenesis, Vol. 9, Issue 4, pp. 42, (2020) (PubMed).
: "Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region." in: Pharmacology research & perspectives, Vol. 6, Issue 6, pp. e00441, (2019) (PubMed).
: "Differential Roles of Glycogen Synthase Kinase 3 Subtypes Alpha and Beta in Cortical Development." in: Frontiers in molecular neuroscience, Vol. 10, pp. 391, (2017) (PubMed).
: "ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance." in: Oncotarget, Vol. 7, Issue 16, pp. 22448-59, (2017) (PubMed).
: "Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the β-Catenin Pathway." in: PLoS ONE, Vol. 10, Issue 7, pp. e0134122, (2016) (PubMed).
-
: "ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis." in: Oncogenesis, Vol. 9, Issue 4, pp. 42, (2020) (PubMed).
-
- c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
-
别名
- C-Myc
-
背景
-
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Cellular Localization: Nucleus -
分子量
- 49 kDa
-
基因ID
- 4609
-
途径
- p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect
抗原
-
