CDK4 抗体
(2 references)Quick Overview for CDK4 抗体 (ABIN2855529)
抗原
See all CDK4 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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交叉反应
- Cow, 人, 小鼠, 大鼠
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产品特性
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Rabbit Polyclonal antibody to CDK4 (cyclin-dependent kinase 4)
CDK4 antibody -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human CDK4. The exact sequence is proprietary.
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亚型
- IgG
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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 6-295) antibody
CDK4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (N-Term) antibodyCDK4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 211-303) antibodyCDK4 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 4F11 unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305), (C-Term) antibodyCDK4 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB03154 unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 201-303) antibodyCDK4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305) antibodyCDK4 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 241-303) antibodyCDK4 适用: 人, 小鼠, 大鼠, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303), (C-Term) antibodyCDK4 适用: 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303) antibodyCDK4 适用: 人, 大鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 4 (CDK4) (C-Term) antibodyCDK4 适用: 人, 大鼠, 绵羊, Pig, 犬, Cow, 兔, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: PC-12 , 293T
Validation: KO/KD, Orthogonal
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.82 mg/mL
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缓冲液
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway." in: International journal of molecular medicine, Vol. 44, Issue 5, pp. 1687-1696, (2020) (PubMed).
: "Regulation of miR-34b/c-targeted gene expression program by SUMOylation." in: Nucleic acids research, Vol. 46, Issue 14, pp. 7108-7123, (2019) (PubMed).
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: "Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway." in: International journal of molecular medicine, Vol. 44, Issue 5, pp. 1687-1696, (2020) (PubMed).
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- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
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别名
- cyclin dependent kinase 4
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背景
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The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
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分子量
- 34 kDa
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基因ID
- 1019
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UniProt
- P11802
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途径
- Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size
抗原
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