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CASR 抗体

This anti-CASR antibody (ABIN2855018) is a Rabbit Polyclonal antibody detecting CASR in WB, IF, ICC, IHC (p). Suitable for Human.
产品编号 ABIN2855018
发货至: 中国

Quick Overview for CASR 抗体 (ABIN2855018)

抗原

See all CASR 抗体
CASR (Calcium-Sensing Receptor (CASR))

适用

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宿主

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克隆类型

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多克隆

标记

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This CASR antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 交叉反应

    人, 小鼠, 大鼠

    产品特性

    Rabbit polyclonal antibody to Calcium Sensing Receptor (calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism))
    Calcium Sensing Receptor antibody

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human Calcium Sensing Receptor. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: mouse placenta, mouse pancreas, mouse kidney, unboiled TT

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.55 mg/mL

    缓冲液

    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原

    CASR (Calcium-Sensing Receptor (CASR))

    别名

    calcium sensing receptor

    背景

    The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

    Cellular Localization: Cell membrane

    分子量

    121 kDa

    基因ID

    846

    UniProt

    P41180

    途径

    Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
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