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PPARA 抗体 (N-Term)

This anti-PPARA antibody is a Rabbit Polyclonal antibody detecting PPARA in WB, IP, IHC (p), ChIP. Suitable for Human. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN2854934
发货至: 中国

Quick Overview for PPARA 抗体 (N-Term) (ABIN2854934)

抗原

See all PPARA 抗体
PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))

适用

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宿主

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克隆类型

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多克隆

标记

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This PPARA antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Chromatin Immunoprecipitation (ChIP)

质量等级

KO Validated
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    N-Term

    交叉反应

    Bee, 人, 小鼠, 植物, 大鼠

    产品特性

    Rabbit Polyclonal antibody to PPAR alpha (peroxisome proliferator-activated receptor alpha)
    PPAR alpha antibody

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the N-terminus region of human PPAR alpha. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Validation: KO/KD, Orthogonal, Overexpression

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.39 mg/mL

    缓冲液

    1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Kubo, Hoshi, Matsumoto, Irie, Oura, Tsutsumi, Hata, Yamamoto, Saito: "Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice." in: Lipids in health and disease, Vol. 16, Issue 1, pp. 106, (2018) (PubMed).

    Song, Qu, Zhang, Jiang, Zhou, Jiang, Li, Zhang, Yan: "Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet." in: Scientific reports, Vol. 7, pp. 41604, (2018) (PubMed).

    Chung, Liu, Lin, Chi, Huang, Yang, Yeh, Tan, Lin: "ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance." in: Oncotarget, Vol. 7, Issue 16, pp. 22448-59, (2017) (PubMed).

  • 抗原

    PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))

    别名

    peroxisome proliferator activated receptor alpha

    背景

    Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers, this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

    分子量

    52 kDa

    基因ID

    5465

    UniProt

    Q07869

    途径

    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Hepatitis C
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