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WNT4 抗体 (Center)

WNT4 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2854927
发货至: 中国
  • 抗原 See all WNT4 抗体
    WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))
    抗原表位
    • 15
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    适用
    • 52
    • 33
    • 23
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 45
    • 5
    • 2
    • 1
    克隆类型
    • 48
    • 5
    多克隆
    标记
    • 30
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This WNT4 antibody is un-conjugated
    应用范围
    • 46
    • 18
    • 13
    • 13
    • 11
    • 10
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    产品特性
    Rabbit Polyclonal antibody to WNT4 (protein Wnt-4)
    WNT4 antibody
    纯化方法
    Purified by antigen-affinity chromatography.
    免疫原
    Recombinant protein encompassing a sequence within the center region of human WNT4. The exact sequence is proprietary.
    亚型
    IgG
  • 应用备注
    Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:10000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:10000*
    说明

    Positive Control: 293T , HepG2 , WNT4 transfected 293T lysate , V5-human Wnt4-transfected 293T

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.78 mg/mL
    缓冲液
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    储存液
    Thimerosal (Merthiolate)
    注意事项
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Bai, Huo, Chen, Guo, Xu, Fang, Zhang, Zhang: "Effect of Huayu Tongluo Herbs on Reduction of Proteinuria via Inhibition of Wnt/β-Catenin Signaling Pathway in Diabetic Rats." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 3054145, (2017) (PubMed).

  • 抗原
    WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))
    别名
    WNT4 (WNT4 产品)
    别名
    CG4698 antibody, DWnt-4 antibody, DWnt4 antibody, Dm DWnt4 antibody, Dmel\\CG4698 antibody, Dwnt4 antibody, Wnt antibody, Wnt-4 antibody, anon-EST:Liang-2.4 antibody, clone 2.4 antibody, wnt-4 antibody, wnt4 antibody, SERKAL antibody, WNT-4 antibody, Xwnt4 antibody, xwnt-4 antibody, zgc:136737 antibody, Wnt family member 4 antibody, Wnt oncogene analog 4 antibody, wingless-type MMTV integration site family, member 4 antibody, wingless-type MMTV integration site family member 4 S homeolog antibody, wingless-type MMTV integration site family, member 4a antibody, WNT4 antibody, Wnt4 antibody, wnt4.S antibody, wnt4a antibody
    背景
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98 % amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.

    Cellular Localization: Secreted , extracellular space , extracellular matrix
    分子量
    39 kDa
    基因ID
    54361
    途径
    WNT signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cell-Cell Junction Organization, Tube Formation
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