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BMP4 抗体

This anti-BMP4 antibody is a 兔 多克隆 antibody detecting BMP4 in WB, ICC, IF 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN2854883
发货至: 中国

Quick Overview for BMP4 抗体 (ABIN2854883)

抗原

See all BMP4 抗体
BMP4 (Bone Morphogenetic Protein 4 (BMP4))

适用

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宿主

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克隆类型

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多克隆

标记

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This BMP4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 特异性

    This antibody is able to recognize full length BMP4 protein (~55 kDa) and N-terminal propeptide BMP4 protein (~40 kDa) but unable to detect mature form.

    交叉反应

    人, 小鼠

    产品特性

    Rabbit Polyclonal antibody to BMP4 (bone morphogenetic protein 4)
    BMP4 antibody

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human BMP4. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: NIH-3T3 , JC , HepG2 conditioned medium

    Validation: Orthogonal

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.36 mg/mL

    缓冲液

    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Guo, Wang, Yuan, Zhu, Fu, Xu, Wu, Wu: "TSA restores hair follicle-inductive capacity of skin-derived precursors." in: Scientific reports, Vol. 9, Issue 1, pp. 2867, (2020) (PubMed).

    Peng, Chen, Wang, Zhu, Wu, Luo, Zuo, Luo, Zhou, Shi, Weng, Huang, He, Fan: "Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes." in: Aging, Vol. 11, Issue 23, pp. 11520-11540, (2019) (PubMed).

  • 抗原

    BMP4 (Bone Morphogenetic Protein 4 (BMP4))

    别名

    bone morphogenetic protein 4

    背景

    The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

    Cellular Localization: Secreted , extracellular space , extracellular matrix

    分子量

    47 kDa

    基因ID

    652

    UniProt

    P12644

    途径

    Steroid Hormone Mediated Signaling Pathway, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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