UNG 抗体
Quick Overview for UNG 抗体 (ABIN2854428)
抗原
See all UNG 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 斑马鱼
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产品特性
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Rabbit Polyclonal antibody to UNG (uracil-DNA glycosylase)
UNG antibody -
纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the center region of human UNG. The exact sequence is proprietary.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "Uracil-DNA glycosylase is involved in DNA demethylation and required for embryonic development in the zebrafish embryo." in: The Journal of biological chemistry, Vol. 289, Issue 22, pp. 15463-73, (2014) (PubMed).
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: "Uracil-DNA glycosylase is involved in DNA demethylation and required for embryonic development in the zebrafish embryo." in: The Journal of biological chemistry, Vol. 289, Issue 22, pp. 15463-73, (2014) (PubMed).
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- UNG (Uracil-DNA Glycosylase (UNG))
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别名
- uracil DNA glycosylase
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背景
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This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2.
Cellular Localization: Isoform 1: Mitochondrion , Isoform 2: Nucleus -
分子量
- 35 kDa
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基因ID
- 7374
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UniProt
- P13051
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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