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LIG1 抗体 (C-Term)

This anti-LIG1 antibody (ABIN2854412) is a Rabbit Polyclonal antibody detecting LIG1 in WB. Suitable for Human.
产品编号 ABIN2854412
发货至: 中国

Quick Overview for LIG1 抗体 (C-Term) (ABIN2854412)

抗原

See all LIG1 抗体
LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))

适用

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宿主

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克隆类型

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多克隆

标记

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This LIG1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    C-Term

    交叉反应

    产品特性

    Rabbit polyclonal antibody to DNA ligase I (ligase I, DNA, ATP-dependent)
    DNA ligase I antibody [C2C3], C-term

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the C-terminus region of human DNA ligase I. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: A431 , H1299

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Liddiard, Ruis, Kan, Cleal, Ashelford, Hendrickson, Baird: "DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase." in: Nucleic acids research, Vol. 47, Issue 5, pp. 2402-2424, (2019) (PubMed).

  • 抗原

    LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))

    别名

    DNA ligase 1

    背景

    LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.

    Cellular Localization: Nucleus

    分子量

    102 kDa

    基因ID

    3978

    UniProt

    P18858

    途径

    Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
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