LIG1 抗体 (C-Term)
Quick Overview for LIG1 抗体 (C-Term) (ABIN2854412)
抗原
See all LIG1 抗体适用
宿主
克隆类型
标记
应用范围
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                                            抗原表位
- C-Term
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                                            交叉反应
- 人
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                                            产品特性
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                        Rabbit polyclonal antibody to DNA ligase I (ligase I, DNA, ATP-dependent)
 DNA ligase I antibody [C2C3], C-term
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                                            纯化方法
- Purified by antigen-affinity chromatography.
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                                            免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human DNA ligase I. The exact sequence is proprietary.
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                                            亚型
- IgG
 
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                                            应用备注
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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                                            说明
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                        Positive Control: A431 , H1299 
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- 1 mg/mL
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                                            缓冲液
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
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                                            储存液
- Thimerosal (Merthiolate)
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                                            注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- 4 °C,-20 °C
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                                            储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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    - 
                                            : "DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase."    in: Nucleic acids research, Vol. 47, Issue 5, pp. 2402-2424, (2019)         (PubMed).        
 
 
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                                            : "DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase."    in: Nucleic acids research, Vol. 47, Issue 5, pp. 2402-2424, (2019)         (PubMed).        
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    - LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))
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                                            别名
- DNA ligase 1
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                                            背景
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                        LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. 
 Cellular Localization: Nucleus
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                                            分子量
- 102 kDa
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                                            基因ID
- 3978
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                                            UniProt
- P18858
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                                            途径
- Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
 抗原
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