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- 抗原 See all HLA-DRB4 抗体
- HLA-DRB4 (Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4))
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抗原表位
- Center
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HLA-DRB4 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 产品特性
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Rabbit polyclonal antibody to HLA-DRB4 (major histocompatibility complex, class II, DR beta 4)
HLA DR beta antibody [N1C3] - 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein encompassing a sequence within the center region of human HLA DR beta. The exact sequence is proprietary.
- 亚型
- IgG
- Top Product
- Discover our top product HLA-DRB4 Primary Antibody
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anti-Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4) (AA 30-266) antibody
HLA-DRB4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4C8 unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4) (AA 30-227) antibodyHLA-DRB4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4) antibodyHLA-DRB4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4) (AA 1-266) antibodyHLA-DRB4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4) antibodyHLA-DRB4 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4) antibodyHLA-DRB4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*
- 说明
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Positive Control: Raji
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- 抗原
- HLA-DRB4 (Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4))
- 别名
- HLA-DRB4 (HLA-DRB4 产品)
- 别名
- DR-4 antibody, DR4 antibody, DRB4 antibody, HLA-DR4B antibody, major histocompatibility complex, class II, DR beta 4 antibody, HLA-DRB4 antibody
- 背景
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HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Cellular Localization: Membrane, Single-pass type I membrane protein - 分子量
- 30 kDa
- 基因ID
- 3126
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response
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