FOXP3 抗体 (Biotin)
Quick Overview for FOXP3 抗体 (Biotin) (ABIN2853612)
抗原
See all FOXP3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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                                            特异性
- This antibody reacts with mouse Foxp3.
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                                            纯化方法
- Protein G agarose
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                                            亚型
- IgG2b
 
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                                            应用备注
- Optimal working dilution should be determined by the investigator.
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                                            限制
- 仅限研究用
 
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                                            浓度
- 0.2 mg/mL
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                                            缓冲液
- PBS containing 1 % BSA and 0.09 % NaN3
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                                            储存条件
- 4 °C
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                                            储存方法
- Store at 2-8 °C.
 
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    - FOXP3 (Forkhead Box P3 (FOXP3))
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                                            别名
- FOXP3
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                                            背景
- Forkhead-winged helix P3 (Foxp3), also known as Scurfin or JM2, is a 50-55 kDa transcription factor, originally identified as the gene defective in Scurfy mice. Scurfy mice and humans with similar mutations spontaneously develop autoimmune diseases (IPEX). Resent reports revealed that Foxp3 is expressed in CD4 + CD25 + regulatory T cells (Treg cells), and ectopic expression of Foxp3 in CD4 + Foxp3 - T cells induced a Treg-like phenotype in these cells. Importantly, these reports indicate that Foxp3 is a specific marker for Treg cells. Taken together, Foxp3 is believed to be a crucial regulator of the development and function of Treg cells.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin
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                                            基因ID
- 20371
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                                            NCBI登录号
- NP_001186276
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                                            UniProt
- Q99JB6
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                                            途径
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
 抗原
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