BAG4 抗体 (C-Term)
Quick Overview for BAG4 抗体 (C-Term) (ABIN2799014)
抗原
See all BAG4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 381-409, C-Term
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原理
- Rabbit Anti-Human BAG4 (C-term) Antibody
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免疫原
- This BAG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-409 amino acids from the C-terminal region of human BAG4.
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亚型
- Ig Fraction
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应用备注
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Western Blot
Recommended Dilutions
WB: 1:1000BAG4 Antibody (C-term) . -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- BAG4 (BCL2-Associated Athanogene 4 (BAG4))
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别名
- BAG4
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背景
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Target Description: BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
Gene Symbol: BAG4
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分子量
- 49594 Da
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基因ID
- 9530
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UniProt
- O95429
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途径
- Regulation of Actin Filament Polymerization
抗原
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