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CD33 抗体 (N-Term)

This anti-CD33 antibody is a 兔多克隆 antibody detecting CD33 in WB 和 IHC. Suitable for 人.

产品编号 ABIN2798973

发货至: 中国

Quick Overview for CD33 抗体 (N-Term) (ABIN2798973)

抗原

See all CD33 抗体

CD33

适用

178
35
16
13
7
6
3
1

人

宿主

兔

克隆类型

多克隆

标记

This CD33 antibody is un-conjugated

应用范围

118
107
43
40
28
26
26
25
19
18
10
8
6
5
4
2
2
2
2
1
1
1
1
1
1

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product CD33 Primary Antibody

抗原表位
16

16

13

8

8

5

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 12-39, N-Term

原理

Rabbit Anti-Human CD33 (SIGLEC3) (N-term) Antibody

免疫原

This CD33 (SIGLEC3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human CD33 (SIGLEC3).

亚型

Ig Fraction
anti-CD33 (CD33) (AA 101-200) antibody
CD33 适用: 人, 小鼠 FACS, WB, ELISA, IHC (fro), ICC, IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-CD33 (CD33) (AA 15-237) antibody
CD33 适用: 人 FACS, WB, ELISA, IHC 宿主: 小鼠 Monoclonal 2C6B7 unconjugated

anti-CD33 (CD33) (AA 15-237) antibody
CD33 适用: 人 FACS, ELISA, IHC 宿主: 小鼠 Monoclonal 2C6B7 unconjugated

anti-CD33 (CD33) (AA 18-240) antibody
CD33 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-CD33 (CD33) (AA 49-259) antibody
CD33 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-CD33 (CD33) (AA 261-364) antibody
CD33 适用: 人 FACS, WB, ELISA, IHC (fro), IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-CD33 (CD33) (AA 1-364) antibody
CD33 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2D12-G4 unconjugated

anti-CD33 (CD33) antibody
CD33 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-CD33 (CD33) antibody
CD33 适用: 人, Non-Human Primate FACS, WB, IP, IHC (fro), ICC, Func, MS 宿主: 小鼠 Monoclonal WM53 unconjugated

anti-CD33 (CD33) antibody
CD33 适用: 人, Non-Human Primate FACS, WB, IP, IHC (fro), ICC, MS 宿主: 小鼠 Monoclonal WM53 unconjugated

应用备注

Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50The anti-Siglec3 N-term Pab , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated.

限制

仅限研究用
状态

Liquid

浓度

2.0 mg/mL

储存条件

4 °C,-20 °C

储存方法

2-8°C (short-term), -20°C (long-term)
抗原

CD33

别名

CD33

背景

Target Description: SIGLEC3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,6-linked sialic acid, the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. This protein Induces apoptosis in acute myeloid leukemia (in vitro). It has been shown to interact with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. SIGLEC3 expresses in monocytic/myeloid lineage cells, and contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. The gene for SIGLEC3 belongs to the immunoglobulin superfamily.
Gene Symbol: CD33

分子量

39825 Da

基因ID

945

UniProt

P20138

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