Integrin beta 7 抗体 (C-Term)
Quick Overview for Integrin beta 7 抗体 (C-Term) (ABIN2798921)
抗原
See all Integrin beta 7 (ITGB7) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 737-765, C-Term
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原理
- Rabbit Anti-Human ITGB7 (C-term) Antibody
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免疫原
- This ITGB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-765 amino acids from the C-terminal region of human ITGB7.
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亚型
- Ig Fraction
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应用备注
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Western Blot
Recommended Dilutions
WB: 1:1000ITGB7 Antibody (C-term) . -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- Integrin beta 7 (ITGB7)
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别名
- ITGB7
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背景
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Target Description: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
Gene Symbol: ITGB7
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分子量
- 86903 Da
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基因ID
- 3695
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UniProt
- P26010
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途径
- Integrin Complex
抗原
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