TLR6 抗体 (C-Term)
Quick Overview for TLR6 抗体 (C-Term) (ABIN2798862)
抗原
See all TLR6 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 393-423, C-Term
-
原理
- Rabbit Anti-Human TLR6 (C-term) Antibody
-
免疫原
- This TLR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 393-423 amino acids from the C-terminal region of human TLR6.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
-
Flow Cytometry, Western Blot, Immunohistochemistry
Recommended Dilutions
FC: 1:10-50, WB: 1:1000, IHC: 1:50-100Flow cytometric analysis of NCI-H460 cells using TLR6 Antibody (C-term) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.Western blot analysis of anti-TLR6 Pab , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 2.0 mg/mL
-
储存条件
- 4 °C,-20 °C
-
储存方法
- 2-8°C (short-term), -20°C (long-term)
-
-
- TLR6 (Toll-Like Receptor 6 (TLR6))
-
别名
- TLR6
-
背景
-
Target Description: TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Gene Symbol: TLR6
-
分子量
- 91880 Da
-
基因ID
- 10333
-
UniProt
- Q9Y2C9
-
途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
-