Nanog 抗体 (N-Term)
Quick Overview for Nanog 抗体 (N-Term) (ABIN2798792)
抗原
See all Nanog (NANOG) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 15-49, N-Term
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原理
- Rabbit Anti-Human NANOG (N-term) Antibody
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免疫原
- This NANOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-49 amino acids from the N-terminal region of human NANOG.
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亚型
- Ig Fraction
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应用备注
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Western Blot, Immunofluorescence, Immunohistochemistry, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IF: 1:10-50, IHC: 1:10-50, FC: 1:10-50Western blot analysis of anti-NANOG Antibody (N-term) . NANOG immunoreactivity is localized to Nucleus significantly. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 2.0 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- Nanog (NANOG) (Nanog Homeobox (NANOG))
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别名
- NANOG
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背景
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Target Description: NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cell proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.
Gene Symbol: NANOG
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分子量
- 34620 Da
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基因ID
- 79923
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UniProt
- Q9H9S0
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途径
- Stem Cell Maintenance
抗原
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