LIN28B 抗体 (Center)
Quick Overview for LIN28B 抗体 (Center) (ABIN2798789)
抗原
See all LIN28B 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 95-128, Center
-
原理
- Rabbit Anti-Human LIN28B (Center) Antibody
-
免疫原
- This LIN28B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-128 amino acids from the Central region of human LIN28B.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
-
Western Blot, Immunohistochemistry, Flow Cytometry, Immunofluorescence
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50, FC: 1:10-50, IF: 1:10-50Western blot analysis of anti-LIN28B Pab . -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.500 mg/mL
-
储存条件
- 4 °C,-20 °C
-
储存方法
- 2-8°C (short-term), -20°C (long-term)
-
-
- LIN28B (Lin-28 Homolog B (LIN28B))
-
别名
- LIN28B
-
背景
-
Target Description: Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.
Gene Symbol: LIN28B
-
分子量
- 27084 Da
-
基因ID
- 389421
-
UniProt
- Q6ZN17
抗原
-